基于《医疗机构中成药遴选专家共识》的血必净注射液遴选评价

Selection evaluation of Xuebijing Injection by the Experts Consensus on the Selection of Chinese Patent Medicine in Medical Institutions

关键词:  血必净注射液  《医疗机构中成药遴选专家共识》  药品遴选  中成药  遴选评价

Key words:  Xuebijing Injection  Experts Consensus on the Selection of Chinese Patent Medicine in Medical Institutions  drug selection  Chinese patent medicine  selection evaluation

摘要:

[目的]对血必净注射液进行多维度评价,以期为医疗机构中成药遴选及合理用药提供客观、准确的建议。[方法]根据《医疗机构中成药遴选专家共识》对血必净注射液进行全面、系统地评价。[结果]血必净注射液总分71.0分,其中安全性19.0分,有效性17.5分,经济性7.0分,创新性8.0分,适宜性4.5分,可及性7.0分,传承性8.0分。在有效性方面,血必净临床适应证具有不可替代性,既填补了脓毒症治疗空白,同时作为“三药三方”中唯一的注射剂,疗效确切;安全性方面,真实世界数据显示血必净安全性相对较高;在创新性方面,血必净药理作用明确,药代动力学清晰;在适宜性方面,血必净临床定位清晰、贮存方便,但顺应性一般;可及性方面,血必净保证供应、患者可负担性强、生产企业实力强;传承性方面,血必净源自经典名方,中医药特色突出;经济性方面,虽然日均费用相对较高,但通过降低患者病死率带来药物经济学优势。[结论]血必净临床价值较好,医疗机构遴选推荐强度为“推荐”。

Abstract:

[Objective] To provide objective and accurate suggestions for the selection and rational use of Chinese patent medicines in medical institutions by carrying out the multi-dimensional evaluation of Xuebijing Injection. [Methods] According to the Expert Consensus on the Selection of Chinese Patent Drugs in Medical Institutions,Xuebijing Injection was comprehensively and systematically evaluated. [Results] The total score of Xuebijing injection is 71.0 points,including 19.0 points for safety,17.5 points for effectiveness,7.0 points for economy,8.0 points for innovation,4.5 points for suitability,7.0 points for accessibility and 8.0 points for inheritance. In terms of effectiveness,Xuebijing's clinical indications are irreplaceable,filling the gap in the treatment of sepsis and serving as the only injection among the “three drugs and three formulas”,with definite therapeutic effects;in terms of safety,real-world data shows that Xuebijing has relatively high safety;In terms of innovation,Xuebijing has clear pharmacological effects and clear pharmacokinetics;in terms of suitability,Xuebijing has clear clinical positioning and storage,but poor compliance;in terms of accessibility,Xuebijing ensures supply,has strong affordability for patients,and has strong production enterprise strength;in terms of inheritance,Xuebijing originates from classic and famous formulas,with prominent characteristics of traditional Chinese medicine;in terms of economy,although the daily average cost is relatively high,it brings pharmacoeconomic advantages by reducing patient mortality. [Conclusion] Xuebijing has good clinical value and the recommended level of Xuebijing Injection is “recommended”.