半夏泻心汤加味联合四联疗法对脾胃湿热型Hp相关慢性胃炎患者Hp清除率及胃肠黏膜功能的影响

Effect of Banxia Xiexin Decoction combined with quadruple therapy on Hp clearance and gastrointestinal mucosal function in patients with damp-heat Hp-related chronic gastritis of the spleen and stomach

关键词:  半夏泻心汤  四联疗法  脾胃湿热型  幽门螺杆菌  慢性胃炎

Key words:  Banxia Xiexin Decoction  quadruple therapy  spleen and stomach dampness and heat type  Helicobacter pylori  chronic gastritis

摘要:

[目的]探究半夏泻心汤加味联合四联疗法对脾胃湿热型幽门螺杆菌(Hp)相关慢性胃炎患者Hp清除率及胃肠黏膜功能的影响。[方法]收集2020年3月-2022年3月在本院收治的92例脾胃湿热型Hp相关慢性胃炎患者,将患者按照随机法分为对照组45例、研究组47例。对照组患者采用四联疗法予以治疗,而研究组患者则是在对照组的基础上联合半夏泻心汤加味进行治疗,比较两组患者的Hp清除率、胃肠黏膜功能、中医证候积分、胃肠道激素、临床疗效的情况变化。[结果]治疗后两组患者主症、次症积分、丙二醛(MDA)、血管活性肠肽(VIP)表达水平降低,胃泌素-17(GAS-17)、血清胃蛋白酶原I(PGI)、前列腺素E₂(PGE₂)、胃动素、瘦素表达水平升高,且研究组较对照组有所改善(P＜0.05)。与对照组比较,研究组的Hp清除率、临床总有效率升高(P＜0.05)。研究组的临床总有效率比对照组高(P＜0.05)。[结论]半夏泻心汤加味联合四联疗法对治疗脾胃湿热型Hp相关慢性胃炎患者效果显著,可有效减轻患者的中医症状,提升Hp清除率,调节体内的肠道菌群,改善胃肠黏膜功能,值得临床应用。

Abstract:

[Objective] To explore the effect of Banxia Xiexin Decoction combined with quadruple therapy on the Hp clearance and gastric mucosa function in patients with Helicobacter pylori(Hp). [Methods] Collected in March 2020 to March 2022,92 cases of spleen and stomach dampness Hp related chronic gastritis,and the patients were divided into control group 45 cases,47 cases. The control group patients were treated with quadruple therapy,while the study group patients were treated with modified Banxia Xiexin Decoction on the basis of the control group. The changes in Hp clearance rate,gastrointestinal mucosal function,traditional Chinese medicine syndrome score,gastrointestinal hormones,and clinical efficacy of the two groups of patients were compared. [Results] After treatment,the expression levels of primary disease,secondary disease integral,Malondialdehyde(MDA) and vasoactine intrestinal peptide (VIP) were reduced,Gastrin-17(GAS-17),serum pepsinogen I(PGI),prostaglandin E₂(PGE₂),pepin,leptin expression levels,and the study group has improved compared with the control group(P＜0.05). The Hp clearance rate and total clinical effective rate of the study group were higher than those of the control group(P＜0.05). The total clinical response rate in the study group was higher than that in the control group(P＜0.05). [Conclusion] Banxia Xiexin Decoction combined with quadruple therapy has significant effect on the treatment of patients with spleen-stomach damp-heat type HP-related chronic gastritis,which can effectively reduce the symptoms of traditional Chinese medicine,increase the clearance rate of Hp,regulate the intestinal flora in the body,and improve the function of gastrointestinal mucosa,which is worthy of clinical application.