血必净注射液治疗病毒性肺炎的临床证据评价

Clinical evidence evaluation of Xuebijing Injection in the treatment of viral pneumonia

关键词:  病毒性肺炎  血必净注射液  中西医结合  Meta分析  临床证据

Key words:  viral pneumonia  Xuebijing Injection  combination of traditional Chinese and Western medicine  Meta-analysis  clinical evidence

摘要:

[目的] 系统评价血必净注射液治疗病毒性肺炎的临床证据。[方法] 计算机检索中英文数据库，搜集血必净注射液治疗病毒性肺炎的临床研究，检索时限为建库至2024年7月。质量评价根据纳入研究的设计类型选择相应质量评价工具。采用R软件进行Meta分析。[结果] 共纳入10篇文献，研究质量整体不高。Meta分析结果显示，血必净注射液组在症状改善率（发热、乏力、气短）、理化指标（白细胞计数、淋巴细胞计数、C反应蛋白、白介素-6、肿瘤坏死因子）、疾病转归[重症加强护理病房（ICU）住院时间、机械通气使用率、无创机械通气使用率、14 d转重率、急性呼吸窘迫综合征（ARDS）发生率、脓毒性休克发生率）]等有效性指标方面具有优势，组间差异有统计学意义（P<0.05）。在安全性指标方面两组差异无统计学意义（P>0.05）。[结论] 血必净注射液在病毒性肺炎的治疗中安全有效，但研究质量较低，影响了结果的可信度。

Abstract:

[Objective] To systematically evaluate the clinical evidence of Xuebijing Injection in the treatment of viral pneumonia. [Methods] We search the Chinese and English databases to collect the clinical studies of Xuebijing Injection in the treatment of viral pneumonia. The search time limit was from the establishment of the database to July，2024. We selected the appropriate quality evaluation to adapt the design type included in the study and used R software to analyze Meta. [Results] A total of 8 articles were included，and the overall study quality was not elevated. Meta-analysis results showed that the Xuebijing Injection group had advantages in the improvement rate of symptoms（fever，fatigue，shortness of breath），physical and chemical indicators（leukocyte count，lymphocyte count，C-reactive protein，interleukin-6，tumor necrosis factor），disease outcome（length of stay in ICU，use rate of mechanical ventilation，use rate of non-invasive mechanical ventilation，weight conversion rate in 14 days，incidence rate of ARDS，incidence rate of septic shock） and other effective indicators. The difference between groups was statistically significant（P<0.05）. There was no significant difference in safety indexes between the two groups（P>0.05）. [Conclusion] Xuebijing Injection is safe and effective in the treatment of viral pneumonia，but the research quality is low，which affects the reliability of the results.