基于Wnt/β-catenin信号通路补肾活血中药治疗膝骨性关节炎与骨质疏松症“共病”机制研究进展

Progress on the mechanism of traditional Chinese medicines for reinforcing kidney and activating blood circulation in the treatment of knee osteoarthritis and osteoporosis “co-morbidity” based on Wnt/β-catenin signaling pathway

关键词:  Wnt/β-catenin信号通路  补肾活血中药  膝骨性关节炎  骨质疏松症  作用机制  共病

Key words:  Wnt/β-catenin signaling pathway  traditional Chinese medicines for reinforcing kidney and activating blood circulation  osteoarthritis of the knee  osteoporosis  mechanism of action  co-morbidity

摘要:

膝骨性关节炎（KOA）是一种膝关节慢性退行性病变，主要表现为关节疼痛、肿大、僵硬，对患者生活质量造成极大影响。骨质疏松症（OP）是一种全身性代谢性骨病，以骨量低下、骨微结构损坏为主要病理特征，易使患者发生骨折。中药具有多种有效成分，能多靶点、多功效治疗疾病，对治疗共病有极大优势。经典Wnt/β-catenin信号通路以多种途径调节膝关节软骨细胞形成与凋亡及骨细胞增殖和发育，与KOA与OP发病关系紧密。文章通过对补肾活血中药调控Wnt/β-catenin信号通路治疗KOA与OP“共病”的分子机制进行综述，为临床更有效、合理地使用补肾活血中药治疗KOA与OP“共病”提供依据。

Abstract:

Knee osteoarthritis（KOA） is a chronic degenerative disease of the knee joint，mostly manifested by joint pain，swelling，and stiffness，which has a great impact on the quality of life of the patient. Osteoporosis（OP） is a systemic metabolic bone disease，with low bone mass，and bone microstructure damage as the main pathological characteristics，vulnerable to fractures. Chinese medicine has a variety of effective ingredients，multi-targeting，and multi-effective treatment of diseases，which has a great advantage in the treatment of common diseases. The classic Wnt/β-catenin signal pathway regulates the formation of knee joint cartilage cells and the death proliferation and development of bone cells by multiple pathways，which is closely related to the pathogenesis of KOA and OP. This paper reviewed the molecular mechanism of Wnt/β-catenin signaling pathway modulation by kidney tonifying and blood activating traditional Chinese medicines in the treatment of “co-morbidities” of KOA and OP，and provided a basis for more effective and rational use of kidney tonifying and blood activating traditional Chinese medicines in the treatment of “co-morbidities” of KOA and OP. This study will provide a basis for the more effective and rational use of kidney tonifying and blood activating herbs in the treatment of KOA and OP co-morbidities.