中药治疗骨质疏松证据可视化分析及研究热点透视

Visualization analysis of the evidence of traditional Chinese medicine in the treatment of osteoporosis and perspective of research hotspots

关键词:  中药  骨质疏松  研究热点  可视化  证据

Key words:  medicinal herbs  osteoporosis  research hotspots  visualization  evidence

摘要:

[目的] 分析中药治疗骨质疏松的研究现状、研究特点和热点趋势，为中药治疗骨质疏松提供热点透视和未来药物研发建议。[方法] 检索中国知网、维普网、万方数据知识服务平台、中国生物医学文献等中文数据库，以及Web of Science、PubMed等英文数据库中有关中药治疗骨质疏松的文献，检索时间为建库至2024年10月。利用CiteSpace与VOSviewer软件对纳入文献进行证据可视化分析，包括发文趋势、作者及机构合作情况、关键词聚类、共现和突现词分析等，绘制可视化图谱。[结果] 共纳入文献2 525篇。中药治疗骨质疏松相关论文发文量总体呈上升趋势，2023年度发文量最多，共117篇。其中，发表研究数量最多的作者为郑洪新；研究机构主要为各中医药高校和科研院所。研究热点集中在药理作用、细胞分子等方面；研究热门方法以数据挖掘等为主。[结论] 通过可视化分析，从研究主题、对象、方法等要素总结了中药治疗骨质疏松研究相关关键证据及热点趋势，发现中药治疗骨质疏松研究主要集中在药理作用、机制研究方面；研究热点聚焦于中药在骨质疏松导致的腰背痛方面。当前，中医治疗骨质疏松研究的总体趋势是将“细胞实验结局指标”与“骨质疏松相关疾病”建立联系。对分析结果进行可视化呈现，为后续中医治疗骨质疏松相关研究的主题遴选和研究设计提供证据参考。

Abstract:

[Objective] To analyze the research status，research characteristics and hot trends of traditional Chinese medicine in the treatment of osteoporosis，and provide hot spot perspective and suggestions for future traditional Chinese medicine drug research and development in the treatment of osteoporosis. [Methods] Chinese database such as CNKI，VIP，Wanfang Data，Chinese biomedical literature，as well as English databases such as Web of Science and PubMed were searched to obtain literature on the treatment of osteoporosis with traditional Chinese medicine. The search time was from the establishment of the database to October 2024. CiteSpace and VOS viewer software were used to analyze the evidence visualization of the included literature，including the trend of publication，the cooperation of authors and institutions，keyword clustering，co-occurrence and burst word analysis，etc.，and drew the visualization map. [Results] A total of 2 525 articles were included，and the number of published papers on the treatment of osteoporosis with traditional Chinese medicine showed an overall upward trend，with the largest number of published papers in 2023，a total of 117 articles. Among them，the author with the largest number of published studies was ZHENG Hongxin. The research institutions were mainly universities and research institutes of traditional Chinese medicine. The research hotspots mainly focused on pharmacological effects，cell molecules and so on. The popular research methods were mainly data mining. [Conclusion] Through visual analysis，this paper summarized the key evidence and hot trends of traditional Chinese medicine in the treatment of osteoporosis from the aspects of research themes，objects，methods and other elements. This paper found that the research of traditional Chinese medicine in the treatment of osteoporosis mainly focuses on the pharmacological effects and mechanism. Research hotspots focused on the role of traditional Chinese medicine on low back pain caused by osteoporosis. At present，the general trend of traditional Chinese medicine treatment of osteoporosis is to establish a relationship between “cell experiment outcome index” and “osteoporosis-related diseases”. The analysis results were visualized to provide evidence reference for the theme selection and research design of the follow-up research on osteoporosis treated by traditional Chinese medicine.