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| 中医药改善内皮细胞功能障碍治疗动脉粥样硬化的研究进展 |
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赵玉珂1, 郭海珍1, 李晓凤2, 王润英3, 钱舒乐1, 丛紫东2, 杜武勋2
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1.天津中医药大学, 天津 301617;2.天津中医药大学第二附属医院, 天津 300250;3.济源职业技术学院, 济源 459000
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| 摘要: |
| 内皮细胞功能障碍（ECD）是一种病理状态，表现为屏障功能受损、血管舒张减少、氧化应激、促炎状态和促血栓形成状态方面的改变。ECD被认为是动脉粥样硬化（AS）的始动环节。对ECD促进AS的具体机制和改善ECD的中医药治疗策略进行阐述，以期为中医药干预ECD延缓AS进程拓宽思路。 |
| 关键词: 内皮细胞功能障碍 动脉粥样硬化 中医药 |
| DOI：10.11656/j.issn.1672-1519.2025.12.17 |
| 分类号:R541 |
| 基金项目:国家自然科学基金项目（82004329）；全国名老中医药专家传承工作室建设项目（国中医药人教函[2022]75号）；天津市名中医传承工作室建设项目；2024年度天津中医药大学第二附属医院“育才计划”项目。 |
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| Research progress on treating atherosclerosis by improving endothelial cell dysfunction with traditional Chinese medicine |
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ZHAO Yuke1, GUO Haizhen1, LI Xiaofeng2, WANG Runying3, QIAN Shule1, CONG Zidong2, DU Wuxun2
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1.Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China;3.Jiyuan Vocational and Technical College, Jiyuan 459000, China
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| Abstract: |
| Endothelial cell dysfunction（ECD） is a pathological state characterized by impaired barrier function，reduced vasodilation，oxidative stress，as well as a pro-inflammatory and pro-thrombotic status. ECD is regarded as the initiating factor in atherosclerosis（AS）. This review elaborates on the specific mechanisms by which ECD promotes AS and discusses therapeutic strategies using traditional Chinese medicine to ameliorate ECD，aiming to provide new insights for traditional Chinese medicine interventions to delay the progression of AS. |
| Key words: endothelial cell dysfunction atherosclerosis traditional Chinese medicine |
