乌梅丸加减治疗糖尿病及其并发症研究进展

Research progress on Wumei Pill treating type diabetes and its complications

关键词:  乌梅丸  糖尿病及其并发症  厥阴病  研究进展

Key words:  Wumei Pill  diabetes and its complications  Jueyin disease  research progress

摘要:

乌梅丸源自张仲景的《伤寒论》厥阴篇，该方集酸苦甘辛于一体，辛开苦降，刚柔并济，具有“寒热并用、攻补兼施”的配伍特点，既能调和肝脾，又可补虚泻实，被视为治疗上热下寒厥阴病的主方。随着乌梅丸临床应用的不断发展，其治疗范围已拓展至糖尿病及其并发症，并取得了显著的临床疗效。基于此对近十年乌梅丸的相关临床及基础研究进展综述如下，旨在为糖尿病及其并发症的有效治疗提供新思路和新方法，促进乌梅丸在临床得到更加深入与广泛的运用。

Abstract:

The Wumei Pill，derived from ZHANG Zhongjing’s Treatise on Cold Damage Diseases within the Jueyin chapter，is a traditional Chinese medicine formula that integrates sour，bitter，sweet，and pungent tastes. It adheres to the therapeutic principles of using pungency to disperse and bitterness to drain，along with a balance of rigidity and softness，reflecting the strategy of “employing both cold and heat，and combining attack with supplementation”. This formula is renowned for its ability to harmonize the liver and spleen，tonify deficiencies，and purge excesses，making it a primary treatment for Jueyin diseases characterized by upper heat and lower cold. As clinical applications of the Wumei Pill have evolved，its therapeutic indications have broadened to encompass diabetes and its complications，demonstrating notable clinical benefits. This paper reviews the clinical and foundational research advancements of the Wumei Pill over the past decade，with the goal of offering innovative approaches for the effective management of diabetes and its complications，and advocating for a more comprehensive and extensive use of the Wumei Pill in clinical settings.