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针刺治疗膝骨性关节炎的量效关系研究进展
李湘1, 王佳琦1, 张洪侠1,2, 黄菁1, 李若雨1, 袁若愚1, 徐枝芳1,3,4,5
1.天津中医药大学实验针灸学研究中心, 天津 301617;2.天津中医药大学医学技术学院, 天津 301617;3.中医国家临床医学研究中心, 天津 300193;4.天津市现代中医理论创新转化重点实验室, 天津 301617;5.天津中医药大学针灸推拿学院, 天津 301617
摘要:
针刺在膝骨性关节炎治疗中疗效显著,通过不同针灸疗法治疗膝骨性关节炎研究发现,临床多以复式手法或联合治疗为主,适当增加针刺时长和频率,可以提高临床疗效,但刺激参数不一导致针刺治疗膝骨性关节炎缺乏科学严谨的参数量化和标准化,难以复现其疗效,限制针刺疗法推广运用。文章对针刺治疗膝骨性关节炎的干预方式、时间参数及证型与量效关系进行研究,系统分析针刺刺激量与临床疗效之间的量效关系,期望为规范化治疗体系提供循证依据,有助于临床针刺治疗膝骨性关节炎的标准化和推广。
关键词:  膝骨性关节炎  手法  时间  量效
DOI:10.11656/j.issn.1672-1519.2026.06.18
分类号:R684.3
基金项目:国家重点研发计划资助项目(2022YFC3500404);国家自然科学基金面上项目(82474642);天津中医药大学第十五届大学生科技创新基金(KJ1505)。
Research progress on the dose-response relationship of acupuncture in the treatment of knee osteoarthritis
LI Xiang1, WANG Jiaqi1, ZHANG Hongxia1,2, HUANG Jing1, LI Ruoyu1, YUAN Ruoyu1, XU Zhifang1,3,4,5
1.Experimental Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.College of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;3.National Clinical Research Center for Chinese Medicine, Tianjin 300193, China;4.Tianjin Key Laboratory of Modern Chinese Medicine Theory Innovation and Transformation, Tianjin 301617, China;5.College of Acupuncture and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Abstract:
Acupuncture has demonstrated significant efficacy in the treatment of knee osteoarthritis(KOA). Studies on different acupuncture therapies for KOA have revealed that combined manipulations or integrated treatments are predominantly used in clinical practice. Appropriately prolonging acupuncture duration and increasing treatment frequency can enhance clinical outcomes. However, the lack of uniform stimulation parameters has resulted in the absence of scientifically rigorous quantification and standardization of parameters for acupuncture in KOA treatment,making it difficult to replicate its efficacy and thereby limiting the widespread application of acupuncture therapy. This study investigates the intervention methods,time parameters,and the relationship between syndrome types and dose-effect in acupuncture treatment of KOA. It systematically analyzes the dose-effect relationship between acupuncture stimulation dosage and clinical efficacy,aiming to provide evidence-based support for the establishment of a standardized treatment system and facilitate the standardization and popularization of clinical acupuncture in KOA management.
Key words:  knee osteoarthritis  manipulation techniques  time parameters  dose-effect relationship
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