丹酚酸B、丹参酮ⅡA对动脉粥样硬化家兔血清一氧化氮及甘油三酯的影响*

The influence of salvianolic acid B and tanshinone ⅡA on the nitric oxide and triglyceride in sera of atherosclerosis rabbits

关键词:  丹参  丹酚酸B  丹参酮ⅡA  动脉粥样硬化  一氧化氮  甘油三酯

Key words:  red sage root  salvianolic acid B  tanshinoneⅡA  atherosclerosis  nitric oxide  triglyceride

摘要:

[目的]观察丹参水溶性成分丹酚酸B和脂溶性成分丹参酮ⅡA对家兔动脉粥样硬化模型血清一氧化氮(NO)及甘油三酯(TG)浓度的影响,以寻找其作用耙点。[方法]复制家兔动脉粥样硬化模型,分别用放射性免疫方法和比色法检测血清NO和TG浓度,观察丹酚酸B和丹参酮ⅡA抗动脉粥样硬化的作用异同。[结果]丹酚酸B和丹参酮ⅡA都能增加动脉粥样硬化家兔血清NO浓度,降低血清TG浓度。但升高NO的作用丹参酮ⅡA优于丹酚酸B;降低TG作用丹酚酸B优于丹参酮ⅡA。[结论]丹参水溶性成分与脂溶性成分都能调节血清NO及TG浓度而达到抗动脉粥样硬化的作用,但具体作用机制有所不同。

Abstract:

[Objective] To study the influence of water-soluble active principle (salvianolic acid B) and fat-soluble active principle (tanshinoneⅡA) on the level of nitric oxide (NO) and triglyceride (TG) in sera of atherosclerosis rabbits.[Methods] Atherosclerosis was initiated in rabbits by feeding cholesterol and oil.The influence of salvianolic acid B and tanshinoneⅡA on sera NO and TG were observed by radio immunity and GPO-PAP.[Results] Both of the salvianolic acid B and the tanshinoneⅡA could markedly decrease the level of TG and significantly increase the NOW but the tanshinoneⅡA was significantly better than the salvianolic acid B on NO,the salvianolic acid B was better significantly better than the tanshinoneⅡA on TG.[Conclusion] The salvianolic acid B and tanshinoneⅡA both could inhit atherogenesis of hyperlipid-fed rabbits by modulate the NO and TG,but the mechanism is not entire the same.