影响微乳形成因素的研究*

Investigation on the forming factors for micro-emulsion

关键词:  明党参果实  呋喃香豆素  高效液相色谱法

Key words:  micro-emulsion  the pseudo-ternary phase diagrams  oil phase  emulsifier  assistant emulsifier

摘要:

[目的]考察不同因素对微乳形成的影响。[方法]选择聚氧乙烯山梨醇脂肪酸酯-80(Tween80)、聚氧乙烯氢化蓖麻油(CremopherRH40)、聚氧乙烯蓖麻油(CremopherEL35)、聚乙二醇-8-甘油辛酸/癸酸酯(Labrasol)为乳化剂,1,2-丙二醇、Transcutol为助乳化剂,麻油、辛癸酸甘油酯、肉豆蔻酸异丙酯为油相,改变乳化剂和助乳化剂不同质量比(Km),制备微乳,通过绘制相图考察形成微乳区面积的大小。[结果]以CremopherRH40为乳化剂,乙二醇单乙基醚(Transcutol)为助乳化剂,Km为3:1时,不同的油形成微乳的能力:辛癸酸甘油酯>肉豆蔻酸异丙酯>麻油;以辛癸酸甘油酯为油相,Transcutol为助乳化剂,Km为3:1时,不同表面活性剂形成微乳的能力:CremopherRH40、CremopherEL35>Tween80>Labrasol;以辛癸酸甘油酯为油相,CremopherRH40为乳化剂,不同助表面活性剂形成微乳的能力:1,2-丙二醇>Transcutol。[结论]油相分子大小及油相含量、乳化剂、助乳化剂种类及含量均对微乳的形成有影响。

Abstract:

[Objection] To investigate the effect of different factor on the forming of micro-emulsion.[Methods] Tween 80, Cremopher RH40, Cremopher EL35 and Labrasol were selected as the emulsifier, 1,2-propanediol,Transcutol as the assistant emulsifier, Benne oil, Caprylic/Capric Triglyceride, isopropyl myristate as the oil-phase. Changingthe mass ratio(Km)ofthe emulsifier and assistant emulsifier to prepare the micro-emulsion and the formed area of the micro-emulsion was determined through plottingthe pseudo-ternaryphase diagrams. The area of O/W micro-emulsion as the function was studied.[Results] The capability of different oil in forming micro-emulsion was: Caprylic/Capric Triglyceride >isopropyl myristate>Benne oil (when taking CremopherRH40 as emulsifier, Transcutol as assistand emulsifier, Km=3:1). Meanwhile, it was: CremopherRH40>Cremopher EL35> Tween 80>Labrasol(when Caprylic/Capric Triglyceride as oil, Transcutol as emulsifier, Km=3:1) and it was: 1,2-propanediol>Transcutol (when taking Caprylic/CapricTriglyceride as oil, CremopherRH40 as emulsifier).[Conclusions] All the molecular size and the content of oil phase and the kind and content of the emulsifier have effect on the forming of micro-emulsion.