| 摘要: |
| [目的] 探讨丹酚酸B、三七总皂苷协同应用对大鼠离体心脏冠脉流量的影响。[方法] 应用均匀设计的方法,将丹酚酸B与三七总皂苷的不同配比设计为6个水平,应用Langendorff系统进行离体心脏恒压灌流,记录6组实验给药前后大鼠的冠脉流量。[结果] 丹酚酸B与三七总皂苷在升高大鼠冠脉流量上不存在线性回归关系,6组实验中以1号实验丹酚酸B/三七总皂苷为20mg/30mg升高大鼠冠脉流量最佳。[结论] 丹酚酸B、三七总皂苷协同应用对大鼠离体心脏冠脉流量有很大影响。 |
| 关键词: 丹酚酸B 三七总皂苷 离体心脏 |
| DOI：10.11656/j.issn.1673-9043.2008.04.11 |
| 分类号: |
| 基金项目:* 国家重点基础研究发展计划973计划课题(2005CB523404) |
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| Effect of different matching of salvianolic Acid B and panax Pseudo-ginseng total saponin on coronary artery flow of isolated heart in rats |
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LI Yu-hong,XU Qiang,GAO Xiu-mei
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Tianjin University of TCM, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin 300193, China
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| Abstract: |
| [Objective] To explore the effect of different matching of salvianolic acid B combined with and panax pseudo-ginseng total saponin on coronary artery flow of isolated heart in rats.[Methods] Six levels of different matching of salvianolic acid B and panax pseudo-ginseng total saponin were designed.Constant pressure perfusion of isolated heart was carried out by using Langendorff system and the coronary artery flow rate was recorded.[Results] There wasn't linear regression relation in enhancing coronary artery flow rate when salvianolic acid B and panax pseudo-ginseng total saponin were used.The 20 mg:30 mg dosage group was the best for increasing the coronary artery flow rate in rats.[Conclusion] Different matching of salvianolic acid B and panax pseudo-ginseng total saponin has a tremendous effect on coronary artery flow rate of isolated heart in rats. |
| Key words: salvianolic acid B panax pseudo-ginseng total saponin isolated heart |
