| 摘要: |
| [目的] 测定黄柏中有效成分盐酸小檗碱在大鼠体内的药代动力学参数。[方法] 使用高效液相色谱(HPLC)检测黄柏中盐酸小檗碱在大鼠血浆中的血药浓度;并运用3p97程序对黄柏中盐酸小檗碱的药代动力学参数进行拟合。[结果] 黄柏中盐酸小檗碱在大鼠体内药代动力学参数是:血药浓度曲线下面积(AUC)=774.3(mg·L)/min肾排泄速度常数(Ke)=7.285×10-3L/min,吸收速度常数(Ka)=4.166×10-2L/min,吸收半衰期[T1/2(Ka)]=16.64min,肾排泄半衰期[T1/2(Ke)]=95.15min,出风时间[T(peak)]=50.73min,最大血药浓度[C(max)]=3.898mg/L。[结论] 黄柏中盐酸小檗碱在大鼠体内呈一室模型分布。 |
| 关键词: HPLC 黄柏 盐酸小檗碱 药代动力学 |
| DOI：10.11656/j.issn.1673-9043.2008.04.12 |
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| Pharmacokinetic study of berberine hydrochloride of cortex phellodendri in rat plasma |
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XIAO Xue-feng,QIAO Xiao-li,GAO Lan
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Tianjin University of TCM, Tianjin 300193, China
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| Abstract: |
| [Objective] To study pharmacokinetics of berberine hydrochloride in Cortex Phel-lodendri in the rat.[Methods] Use HPLC to determine serum concentrations of berberine hy-drochloride in Cortex Phellodendri in rat pLasma.The pharmacokinetic parameters of berberine hydrochloride was fitted with 3p97 procedure.[Result] The pharmacokinetic parameters of berberine hydrochloride in Cortex Phellodendri were AUC=774.3 (mg·L)/min,Ke=7.285×10-3 L/min, Ka=4.166×10-2 L/min,T1/2 (Ka)=16.64 min,T1/2 (Ke)=95.15 min,T (peak)=50.73 min,C (max)=3.898 mg/L.[Conclusion] The berberine hydrochloride in Cortex Phellodendri showed one-compartment in the body of Wistar rats. |
| Key words: HPLC cortex phellodendri berberine hydrochloride pharmacokinetics |
