| 摘要: |
| [目的]旨在观察大黄酸对小胶质细胞细胞株的作用。[方法]培养小胶质细胞细胞株,检测大黄酸对小胶质细胞活力及内毒素(LPS)诱导小胶质细胞一氧化氮(NO)产生的影响。[结果]大黄酸可以在不影响细胞活力的情况下抑制NO在激活小胶质细胞中的产生。[结论]大黄酸可以抑制LPS对小胶质细胞的激活。 |
| 关键词: 大黄酸 小胶质细胞 炎性反应 |
| DOI：10.11656/j.issn.1673-9043.2012.01.12 |
| 分类号: |
| 基金项目:* 国家自然科学基金青年项目(81001654);天津市卫生局科技基金(2010KZ120) |
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| Effects of 1.8-Dihydroxy-3-carboxy-anthraquinone on LPS-induced microglial activation |
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JING Hao-ran, CHAI Li-juan, GUO Hong, LI Mei-jiao, LIU Qing-qing, WANG Shao-xia
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Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China
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| Abstract: |
| [Objective] This study examined whether 1.8-Dihydroxy-3-carboxy-anthraquinone,a metabolite from Salvia miltiorrhiza,may exert an anti-inflammatory effect in microglia.[Methods] We examined the effect of 1.8-Dihydroxy-3-carboxy-anthraquinone on cell viability and the production of nitric oxide (NO) induced by LPS treatment in rat primary cultured microglia.[Results] 1.8-Dihydroxy-3-carboxy-anthraquinone could significantly inhibit the production of NO by LPS treatment in rat primary cultured microglia.[Conclusion] 1.8-Dihydroxy-3-carboxy-anthraquinone can suppress microglial activation and this may be a mechanism underlying the neuroprotective activity of it. |
| Key words: 1.8-Dihydroxy-3-carboxy-anthraquinone microglia inflammation |
