| 摘要: |
| [目的]比较不同类型环糊精(α-环糊精、β-环糊精、γ-环糊精)对莪术油的包合效果,研究莪术油环糊精包合物的最佳制备工艺。[方法]采用饱和水溶液法,制备α-环糊精、β-环糊精、γ-环糊精的莪术油包合物并采用X射线衍射法检识包合效果;采用L9(34)正交实验设计表,优化莪术油β-环糊精包合物的最佳制备工艺。[结果]在同一条件下,α-环糊精无法与莪术油形成包合物,γ-环糊精与β-环糊精的包合率几乎相同。以包合率、油利用率为指标,莪术油β-环糊精包合物的制剂最佳工艺为A3B1C2。即β-环糊精:油(g/mL)为8:1,包合温度为40℃,包合时间为90min,按最佳处方的工艺参数反复进行3次实验,挥发油包合率为90.90%,油利用率为66.67%,相对标准偏差(RSD)<2.7%。验证结果表明包合物与环糊精、挥发油和环糊精的物理混合物的X射线图谱有差别。[结论]选取β-环糊精进行莪术油包合,工艺合理,节约成本。 |
| 关键词: 莪术油 环糊精 包合物 制备工艺 |
| DOI：10.11656/j.issn.1673-9043.2012.02.14 |
| 分类号: |
| 基金项目:* 天津市高等学校科技发展基金项目(20110206) |
|
| Investigation of processing technology of zedoary turmeric oil-cyclo dextrin inclusion compound |
|
WANG Yan1, ZHANG Tie-jun2
|
|
1.Tianjin University of TCM, Tianjin 300193 China;2.Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
|
| Abstract: |
| [Objective] To compare the inclusion effect of different types of cyclodextrin (αcyclodextrin, βcyclodextrin, γcyclodextrin) on zedoary turmeric oil, study the best preparation technology of zedoary turmeric oil and cyclodextrin inclusion compound.[Methods] Using the saturated water solution method, α-cyclodextrin, βcyclodextrin, γ-cyclodextrin zedoary turmeric oil inclusion compound were prepared and using X ray diffraction method the inclusion effect was identified; using L9 (34) orthogonal experimental design, the best preparation technology of zedoary turmeric oil and cyclodextrin inclusion compound was optimized.[Results] Under the same conditions, αcyclodextrin and zedoary turmeric oil could not form inclusion compound, the inclusion rate of γ-cyclodextrin and βcyclodextrin inclusion rate were almost the same. Taking the inclusion rate and oil utilizing rate as the indexes, the optimum process of zedoary turmeric oil and β-cyclodextrin inclusion compound was 8:1 of A3B1C2:β-cyclodextrin: Oil (g/mL), the inclusion temperature was 40℃ and the inclusion time was 90 min. According to the best prescription process parameters 3 experiments were repeatedly performed. It was found that the volatile oil inclusion rate was 90.90% and the oil utilizing rate was 66.67%, RSD<2.7% . The results showed that physical mixture of X ray spectrum was different between inclusion complexes with cyclodextrins and volatile oil with cyclodextrin.[Conclusion] The technology is reasonable and the cost can be saved when selecting β-cyclodextrin inclusion zedoary turmeric oil. |
| Key words: zedoary turmeric oil cyclodextrin inclusion compound processing technology |
