逐瘀通脉联合长春西汀对慢性脑供血不足患者血浆H2S、CBS水平变化的影响

Influence of Zhuyu Tongmai capsule combined with Vinpocetine on level of H2S and CBS in patients with chronic cerebral circulation insufficiency

关键词:  逐瘀通脉胶囊  长春西汀注射液  慢性脑供血不足  血浆硫化氢  胱硫醚-β-合酶

Key words:  Zhuyu Tongmai capsule  Vinpocetine injection  CCCI  H₂S  CBS

摘要:

[目的]观察逐瘀通脉联合长春西汀对慢性脑供血不足患者血浆硫化氢（H₂S）、胱硫醚-β-合酶（CBS）水平变化的影响。[方法] 将150 例慢性脑供血不足患者随机分为3 组，每组50 例，粤组口服逐瘀通脉胶囊；B 组静脉输入长春西汀注射液；C 组采用逐瘀通脉胶囊联合长春西汀注射液治疗，3 组都采用常规用药（抗血小板、营养神经、脑细胞活化剂）为基础治疗。观察比较各组血浆CBS、H₂S 水平变化。[结果] 3 组治疗后血浆中CBS、H₂S 水平均有所下降，与治疗前比较，差异有统计学意义（P<0.05）；悦组治疗后CBS、H₂S 水平，分别与A 组、B 组比较，差异有统计学意义（P<0.05）；A组治疗后血清中CBS 水平，与B 组比较，差异有统计学意义（P<0.05）。[结论] 逐瘀通脉联合长春西汀协同作用可降低血浆中CBS、H₂S 含量，改善慢性脑供血不足临床症状，降低复发率。

Abstract:

[Objective] To study the influence of Zhuyu Tongmai (removing stasis and promoting circulation) capsule combined with Vinpocetine on the level of H₂S and CBS in patients with chronic cerebral circulation insufficiency. [Methods] One hundred and fifty patients with chronic cerebral insufficiency were randomly divided in three groups. Patients in group A was treated with Zhuyu Tongmai capsule, group B with Vinpocetine injection and group C with Zhuyu Tongmai capsule and Vinpocetine injection. Each group took the conventional treatment as basic treatment. The level of CBS and H₂S in each group were observed and compared. [Results] The plasma level of CBS and H₂S in patients with cerebral blood deficiency of group C was obviously higher than that in group A and B with significant statistical difference(P<0.05). [Conclusion] Zhuyu Tongmai capsule combined with Vinpocetine injection can reduce plasma level of CBS and H₂S, improve symptoms in patients with chronic cerebral circulatory insufficiency and reduce the rate of recurrence.