| 摘要: |
| [目的] 探究不同剂量川芎天麻汤对小鼠中枢神经系统的影响。[方法] 以旷场实验观察实验药物对小鼠运动时间、路程和中央区停留时间的影响。[结果] 川芎天麻汤3、12、24、36 g/kg均能使小鼠在旷场中的静止时间增加,运动路程减少。[结论] 不同剂量的川芎天麻汤对小鼠中枢神经均有抑制作用,且有剂量依赖性。 |
| 关键词: 川芎 天麻 旷场实验 中枢神经系统 |
| DOI：10.11656/j.issn.1673-9043.2015.05.07 |
| 分类号: |
| 基金项目:辽宁中医药大学“大学生创新创业训练计划”资助项目(201310162031). |
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| Effect of Chuanxiong Tianma decoction on the central nervous system in mice |
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LIU Qing1, WANG Tian-tian1, LIANG Yuan1, FU Yan-jun2
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1.The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China;2.School of Basic Medicine Science, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China
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| Abstract: |
| [Objective] To explore the effects of different doses of Chuanxiong Tianma decoction on the central nervous system in mice. [Methods] Observe the effects of test drugs on mice of activity time, movement distance and still time in the central zone by the way of open field test. [Results] The movement distance decreased and still in the open field time increased by 3, 12, 24 and 36 g/kg of Chuanxiong Tianma decoction. [Conclusion] Different doses of Chuanxiong Tianma decoction can inhibit the central nervous system of mice in a dose-dependent manner. |
| Key words: Chuanxiong Tianma open field test central nervous system |
