中西医结合治疗女童特发性中枢性性早熟36例临床分析

Clinical analysis of 36 cases of idiopathic central precocious puberty treated by traditional Chinese medicine and Western medicine

关键词:  特发性中枢性性早熟  促性腺激素释放激素类似物  大补阴丸  临床分析

Key words:  ICPP  GnRHa  Dabuyin Wan  clinical analysis

摘要:

[目的] 比较中西医结合治疗与单纯西医治疗女童特发性性早熟(ICPP)的临床疗效。[方法] 选取天津市南开医院儿科内分泌门诊符合ICPP诊断的女童患儿72例,随机分为中西医结合组和西医治疗组。中西医结合组服用中药(滋阴泻火法,以大补阴丸为基础方加减),并辅助促性腺激素释放激素类似物(GnRHa);西医治疗组采用常规GnRHa治疗。两组均治疗1.5a后评估疗效与经济负担,统计两组治疗ICPP的总有效率。[结果] 中西医结合组总有效率为77.78%,西医治疗组总有效率为80.56%,两组间疗效差异无统计学意义。但中西医结合组的经济负担明显低于西医治疗组,且不良反应少于西医治疗组。[结论] 中西医结合方法治疗女童ICPP在临床疗效上和西医常规治疗相当,且对生长轴抑制作用降低、不良反应少、经济负担更小。

Abstract:

[Objective] To compare the clinical effect of traditional Chinese medicine and Western medicine(TCM-WM) and Western medicine in treatment of girls with idiopathic central precocious puberty(ICPP). [Methods] Tianjin Nankai hospital pediatric endocrinology clinic 72 patients with diagnosis of ICPP girl children were selected randomly assigned to TCM-WM group and the western medicine group. TCM-WM group were treated with traditional Chinese medicine (for nourishing yin and purging fire, to Dabuyin Wan based square to add and subtract), and auxiliary gonadotropin releasing hormone analogue (GnRHa); the western medicine group was treated with conventional GnRHa. Evaluation of efficacy and economic burden after two groups were treated for a year and a half, statistics of two groups total effective for the treatment of ICPP. [Result] the total effective rate of the TCM-WM group was 77.8%, the total effective rate was 80.56% in the western medicine group, the difference was not statistically significant between the two groups. However, the economic burden of the TCM-WM group was significantly lower than that in the western medicine group, and the adverse reactions were less than that of the western medicine group. [Conclusion] TCM-WM treatment of girls ICPP in the clinical efficacy and conventional treatment of Western medicine, and the inhibition of the growth axis, the adverse reactions less, the economic burden is smaller.