银屑病关节炎中医辨证分型与免疫炎症指标、细胞因子相关性研究

Study on the relationship between TCM syndrome differentiation and immune inflammation indexes, cytokines in psoriatic arthritis

关键词:  银屑病关节炎  中医证型  肿瘤坏死因子-α  白介素-17  白介素-23

Key words:  psoriatic arthritis  syndromes  Tumor Necrosis Factor-alpha  IL-17  IL-23

摘要:

[目的] 观察银屑病关节炎(PsA)不同中医证型与免疫炎症指标、细胞因子相关性。[方法] 将62例确诊为PsA的患者按照中医辨证分型分为湿热内蕴证、寒湿阻络证、阴虚血燥证,检测各组患者的红细胞沉降率(ESR)、C-反应蛋白(CRP)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、肿瘤坏死因子-α(TNF-α)、白介素(IL)-17、IL-23等指标,研究其中医证型与各项指标之间的相关性。[结果] 3组患者IgA、IgG、IgM水平均高于正常范围,但各组间差异无统计学意义(P>0.05),湿热内蕴证患者ESR、CRP、TNF-α、IL-17、IL-23水平显著高于寒湿阻络证及阴虚血燥证患者,差异有统计学意义(P<0.01)。[结论] 银屑病关节炎患者的病情活动程度、免疫功能状态与中医证型存在关联,炎症指标和细胞因子可能作为中医辨证分型的微观指标。

Abstract:

[Objective] To investigate the relationship between different syndromes and immune inflammatory markers, cytokines in psoriatic arthritis (PsA). [Methods] Sixty-two cases of patients diagnosed with PsA were divided into damp-heat syndrome, cold syndrome and YIN-deficiency and blood-dryness syndrome according to Chinese medicine syndrome differentiation criteria. Testing each group of patients ESR、CRP、IgA、IgG、IgM、TNF-α、IL-17、IL-23, study the correlation between indexes and syndromes. [Results] 3 groups of patients IgA, IgG, IgM levels were above the normal range, but no statistically significant difference in each group (i>P> 0.05), damp syndrome patients ESR, CRP, TNF-ɑ, IL-17, IL-23 levels were significantly higher than cold syndrome, YIN-deficiency and blood-dryness syndrome patients, the difference was statistically significant (P< 0.01). [Conclusion] There were association between the degree of disease activity,immune function and syndrome in patients with PsA. Inflammatory markers and cytokines may be used as microscopic indicators of TCM dialectical type.