| 本文已被：浏览 2062次 下载 1777次 |
码上扫一扫！ |
|
|
| 丹参酮I固体脂质纳米粒的制备及评价 |
|
张谦1,2, 刘志东1,2, 秦璐1,2, 顾星1,2, 冯光维1,2
|
|
1.天津中医药大学, 现代中药发现与制剂技术教育部工程研究中心, 天津 300193;2.天津中医药大学, 天津市现代中药重点实验室一省部共建国家重点实验室培育基地, 天津 300193
|
|
| 摘要: |
| [目的] 制备丹参酮I固体脂质纳米粒(TSI-SLN)并对其性质质量进行考察。[方法] TSI-SLN的制备方法选用乳化固化法,并以制剂的粒径、电位和包封率为考察指标。对TSI-SLN冻干品进行差式扫描量热法(DSC)检测。[结果] TSI-SLN的平均粒径为(128±2.00)nｍ,电位为(-9.35±0.12)mV;TSI的包封率为(74.03±1.32)%。DSC结果表明丹参酮I包裹在纳米粒中。[结论] 采用乳化固化法安全可靠,简单易行;该方法下制备的SLN具有较小的粒径和较高的包封率;且理化性质稳定,为后续实验提供了依据。 |
| 关键词: 丹参酮I 固体脂质纳米粒 制备 评价 |
| DOI：10.11656/j.issn.1673-9043.2016.02.12 |
| 分类号: |
| 基金项目:新世纪优秀人才支持计划(NCET-12-1068)。 |
|
| Preparation and evaluation of Tanshinone I solid lipid nanoparticles |
|
ZHANG Qian1,2, LIU Zhi-dong1,2, QIN Lu1,2, GU Xing1,2, FENG Guang-wei1,2
|
|
1.Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China;2.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China
|
| Abstract: |
| [Objective] To prepare Tanshinone I solid lipid nanoparticles (TSI-SLN) and investigate the physicochemical properties.[Methods] TSI-SLN were prepared by using emulsion evaporation-solidification method, and the particle size, Zeta potential and encapsulation efficiency(EE) were determined. And the solid-state characterization ofthe TS I-SLN was analyzed by DSC.[Results] The results showed that the TS I-SLN had average particle size of (128±2.00) nm, zeta potential of (-9.35±0.12) mV and the encapsulation efficiency of (74.03±1.32)%, respectively. DSC results indicated that the drug wrapped in nanoparticles completely.[Conclusion] In this paper, emulsion evaporation-solidification method has chosen for the preparation. The TS I-SLN has superior physical and chemical properties |
| Key words: Tanshinone I solid lipid nanoparticles preparation evaluation |
