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| 正交实验法优化番泻叶的提取工艺 |
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金施施1, 牛换云1, 丁辉1, 武婕1, 余河水1, 李薇1, 曹满2, 宋新波1,2
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1.天津中医药大学, 天津 300193;2.天津中一制药有限公司, 天津 300193
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| 摘要: |
| [目的] 优选番泻叶中番泻苷的最佳提取工艺。[方法] 建立同时测定番泻叶中番泻苷A和番泻苷B含量的方法,以番泻苷A、B的含量为指标,在单因素考察的基础上,进行正交实验优选最佳提取工艺。[结果] 番泻叶中番泻苷的最佳提取工艺为10倍量0.5%的碳酸氢钠60℃搅拌提取1h。[结论] 优化后的提取工艺稳定可靠,可为番泻苷相关研究和实际生产提供依据。 |
| 关键词: 番泻叶 番泻苷 番泻苷A 番泻苷B 提取工艺 |
| DOI：10.11656/j.issn.1673-9043.2016.02.13 |
| 分类号: |
| 基金项目:天津市组分中药创制与分析服务平台建设(12TXGCCX03800)。 |
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| The orthogonal experiment method to optimize the extraction process of senna |
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JIN Shi-shi1, NIU Huan-yun1, DING Hui1, WU Jie1, YU He-shui1, LI Wei1, CAO Man2, SONG Xin-bo1,2
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1.Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Tianjin Zhongyi Pharmaceutical Co.Ltd,Tianjin 300193, China
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| Abstract: |
| [Objective] To select the best extraction process of sennoside from senna. [Methods] To establish the method for simultaneous determination of Sennoside A and Sennoside B, the method utilizes the content of Sennoside A and Sennoside B as a quality control. Based on the single factor, the best extraction process is selected by orthogonal test. [Results] The best process for extraction was 10 fold 0.5% sodium bicarbonate was used to extract Sennoside under 60 ℃ for an hour. [Conclusion] The developed process is stable and reliable, and can be readily utilized for related research and actual production. |
| Key words: senna sennoside sennoside A sennoside B extraction process |
