| 摘要: |
| [目的]研究人参皂苷Re对血小板聚集功能的影响。[方法]采用体外实验通过Born法观察人参皂苷Re对二磷酸腺苷钠盐（ADP）、血小板活化因子（PAF）、花生四烯酸（AA）诱导的家兔血小板聚集率的影响。[结果]人参皂苷Re体外抑制ADP、PAF、AA诱导的家兔血小板聚集差异有统计学意义（P<0.05，P<0.01）。半数抑制浓度（IC50）分别为0.197、0.242、0.443 g/L。[结论]人参皂苷Re呈剂量依赖性抑制体外ADP、PAF、AA诱导的血小板聚集，且抗ADP诱导的血小板聚集作用强于PAF、AA。 |
| 关键词: 人参皂苷Re 血小板聚集 二磷酸腺苷钠盐 血小板活化因子 花生四烯酸 |
| DOI：10.11656/j.issn.1673-9043.2016.05.07 |
| 分类号: |
| 基金项目:国家重点基础研究发展计划（“973”计划）项目资助（2012CB518404）。 |
|
| Effection of Ginsenoside Re on ADP, PAF, AA-induced platelet aggregation |
|
YAN Hai-feng, DAI Xiang-dong, FAN Ke-tao, WANG Yi
|
|
Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China
|
| Abstract: |
| [Objective] To study the effect of ginsenoside Re on platelet aggregation function.[Methods] In vitro, through the Born law, effect of ginsenoside Re on sodium salt adenosine diphosphate (ADP), platelet-activating factor (PAF), arachidonic acid (AA)-induced platelet aggregation rate of.[Results] Ginsenoside Re in vitro ADP, PAF, AA-induced platelet aggregation was statistically significant difference (P<0.05, P<0.01), median inhibiting concentration (IC50), 0.197 g/L, 0.242 g/L, and 0.443 g/L respectively.[Conclusion] The ginsenoside Re in a dose-dependent inhibition of in vitro ADP, PAF, AA-induced platelet aggregation, and ADP-induced platelet aggregation was stronger than PAF, AA. |
| Key words: ginsenoside Re platelet aggregation ADP PAF AA |
