| 摘要: |
| [目的] 对加味香连丸质量控制进行研究。[方法] 采用薄层色谱法对加味香连丸中白芍、当归、黄芩进行定性鉴别，建立高效液相色谱法同时测定加味香连丸中芍药苷、柚皮苷、黄芩苷、厚朴酚的含量。[结果] 白芍、当归、黄芩的薄层色谱鉴别斑点清晰，阴性对照无干扰；高效液相色谱方法测定加味香连丸中芍药苷、柚皮苷、黄芩苷、厚朴酚分别在0.011 68~0.116 8、0.022~0.22、0.255~0.025 5、0.004 1~0.041 g/L范围内线性关系良好，平均回收率分别为98.75%、99.79%、99.22%、99.36%（n=6）；RSD分别为1.63%、1.3%、1.57%、1.6%。[结论] 本法简便易行、准确、重现性良好，为加味香连丸的质量控制提供了理论依据。 |
| 关键词: 加味香连丸 薄层色谱 高效液相色谱法 芍药苷 柚皮苷 黄芩苷 厚朴酚 |
| DOI：10.11656/j.issn.1673-9043.2016.06.13 |
| 分类号: |
| 基金项目:天津市科技计划项目（14TXZYJH00440）。 |
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| The research of quality contral of Jiawei Xianglian pill |
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ZHANG Xiao-xue1, WU Jie1, YU He-shui1, ZHANG Li-juan1, LI Wei1, SONG Xin-bo1,2
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1.Tianjin university of Traditional Chinese Medicine, Tianjin 300193, China;2.Tianjin Zhongyi pharmaceutical Co. Ltd, Tianjin 300193, China
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| Abstract: |
| [Objective] To research the quality control of Jiawei Xianglian pill.[Methods] Paeoniae Radix Alba,Angelicae Sinesis Radix and Scutellaria Radix of Jiawei Xianglian pill was identified by TLC.HPLC was applied to determine the content of paeoniflorin,naringin,baicalin and magnolol.[Results] TLC identification methods had good specificities without interference from negative control.The calibration curves of paeoniflorin,naringin,baicalin and magnolol were linear in the ranges of 0.011 68~0.116 8,0.022~0.22,0.255~0.025 5 and 0.004 1~0.041 mg/mL.The average recoveries wear 98.75%(RSD=1.63%),99.79%(RSD=1.3%),99.22%(RSD=1.57%),99.36%(RSD=1.6%).[Conclusion] This method was simple,pricise and repeatablewhich can be used for quality control of Jiawei Xianglian pill. |
| Key words: Jiawei Xianglian pill TLC HPLC Paeoniflorin Naringin Baicalin Magnolo |
