补肾活血化痰汤对多囊卵巢综合征患者不孕疗效和内分泌代谢的影响

Effect of tonifying kidney, activating blood circulation and resolving phlegm method on endocrine and metabolism in patients with polycystic ovary syndrome and infertility

关键词:  多囊卵巢综合征  胰岛素抵抗  补肾活血化痰  不孕

Key words:  polycystic ovary syndrome  insulin resistance  tonifying kidney,activating blood circulation and resolving phlegm  infertility

摘要:

[目的] 探讨补肾活血化痰汤对多囊卵巢综合征（PCOS）患者不孕疗效和内分泌代谢指标的影响。[方法] 选取2014年1月-2015年11月期间治疗的PCOS不孕患者82例，随机分为观察组与对照组，对照组予口服二甲双胍治疗（每次500 mg，每日3次），观察组在此基础上联合应用自拟补肾活血化痰汤治疗，比较两组患者治疗前后性激素水平及代谢指标的变化，并比较排卵率及妊娠率。[结果] 两组患者黄体生成素（LH）、催乳素（PRL）、睾酮（T）治疗后均明显降低，雌二醇（E₂）明显增高，且组间比较差异有统计学意义（P<0.05）。两组患者体质量指数（BMI）均较治疗前明显下降（P<0.05），但组间比较差异无统计学意义（P>0.05）。两组患者治疗后甘油三酯（TG）、血清胆固醇（TC）、空腹血糖（FPG）、胰岛素抵抗指数（HOMA-IR）均较治疗前显著降低，且观察组低于对照组，差异均有统计学意义（P<0.05）。观察组排卵率及妊娠率均明显高于对照组（P<0.05）。[结论] 补肾活血化痰法治疗PCOS可调节患者性激素水平，改善糖、脂代谢及胰岛素抵抗，提高排卵及妊娠率。

Abstract:

[Objective] This study is to investigate the effect of tonifying kidney activating blood circulation and resolving phlegm method on the endocrine and metabolic indexes of patients with polycystic ovary syndrome (PCOS) and infertility.[Methods] Eighty-two patients with PCOS and infertility treated from Jan 2014 to Nov 2015 were selected, and they were randomly divided into observation group and control group, while the control group was treated by oral Metformin (500 mg, TID), and the observation group combined with decoction of tonifying kidney, activating blood circulation and resolving phlegm based on that, and sex hormone levels and metabolic indicators before and after treatment were compared between the two groups,and the ovulation and pregnancy rate were compared too.[Results] The serum LH, PRL, T in both groups after treatment were significantly reduced, the E₂ was significantly increased, and the difference was of statistically significant between the two groups (P<0.05); the BMI in the two groups were lower than those before treatment, but the difference was of not statistically significant between them (P>0.05). The TG, TC, FPG, HOMA-IR in the two groups after the treatment were lower than those before treatment, and the that in observation group was lower than that of the control group, the differences were of statistically significant (P<0.05). The ovulation rate and pregnancy rate in observation group were significantly higher than the control group (P<0.05).[Conclusion] The method of tonifying kidney, activating blood circulation and resolving phlegm can adjust sex hormone in patients with polycystic ovary syndrome, and improve the glucose, lipid metabolism and insulin resistance, and improve ovulation and pregnancy.