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| 五味降压散镇痛镇静作用的实验研究 |
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李雪丽1, 王伟1, 王佩佩1, 弓铭1, 邓冬1, 李韶菁2, 任莹璐1, 马雪玲1, 赵慧辉1
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1.北京中医药大学, 北京 100029;2.中国中医科学院中药研究所, 北京 100700
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| 摘要: |
| [目的]研究五味降压散的镇痛、镇静作用。[方法]通过醋酸扭体法、热刺激法观察五味降压散对小鼠的镇痛作用；通过悬尾法观察五味降压散对小鼠的镇静作用。[结果]实验表明，五味降压散中剂量能够显著减少小鼠的扭体次数（P<0.05），五味降压散低剂量在给药90 min、高剂量在给药30、90 min时均能显著延长小鼠的痛阈值（P<0.05）；五味降压散高剂量在给药120 min能显著缩短小鼠5 min内悬尾活动时间，延长小鼠5 min内悬尾不动时间。[结论]五味降压散在达到特定剂量时，具有一定的镇痛镇静作用。 |
| 关键词: 五味降压散 镇痛 镇静 |
| DOI：10.11656/j.issn.1673-9043.2018.01.14 |
| 分类号:R289.5 |
| 基金项目:国家自然科学基金项目（81473521，81102730）；北京中医药大学创新团队项目（2011-CXTD-06）；北京市支持中央在京高校共建项目（0101186）；国家自然科学基金青年项目（81503382）；北京中医药大学中青年教师项目（2015-JYB-JSMS036）。 |
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| Experimental study on the analgesic and sedative effects of Wuwei Jiangya formula |
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LI Xueli1, WANG Wei1, WANG Peipei1, GONG Ming1, DENG Dong1, LI Shaojing2, REN Yinglu1, MA Xueling1, ZHAO Huihui1
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1.Beijing University of Chinese Medicine, Beijing 100029, China;2.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
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| Abstract: |
| [Objective] To study the analgesic and sedative effects of Wuwei Jiangya formula.[Methods] Writhing method and heat stimulation method were used to observe the analgesic effect. Tail-hanging test was used to observe the sedative effect of Wuwei Jiangya formula on mice.[Results] The results showed that Wuwei Jiangya formula at medium dose could significantly reduce writhing times of mice. Low dose treatment for 90 min and high dose treatment for 30 min and 90 min could significantly increase mice pain thresholds. Meanwhile, high dose for 120 min extended 5 min tail-hanging immobility time of mice.[Conclusion] Certain dose of Wuwei Jiangya formula may play a role in analgesia and sedation. |
| Key words: Wuwei Jiangya formula analgesic sedative |
