参麦注射液抗阿霉素心脏毒性及其协同放化疗抗肿瘤的作用

Effect of Shenmai injection against doxorubicin cardiotoxicity and its antitumor effect combined with radiotherapy or chemotherapy

关键词:  参麦注射液  阿霉素  心脏毒性  协同抗肿瘤

Key words:  Shenmai injection  doxorubicin  cardiotoxicity  synergistic antitumor

摘要:

参麦注射液来源于《千金要方》之生脉散，临床广泛应用于冠心病、病毒性心肌炎、慢性肺心病等疾病的治疗。近年来，临床和实验研究陆续报道了参麦注射液抗阿霉素心脏毒性的作用，其机制涉及自由基、减轻钙超载、保护线粒体等多个方面。此外，多项研究表明，参麦注射液具有协同放化疗增强抗肿瘤的作用，提示参麦注射液能够在抗肿瘤治疗中发挥扶正祛邪的作用，其机制值得后期进一步研究。

Abstract:

Shenmai injection, which is derived from Shengmaisan in Qianjin Yaofang, is widely used in the clinical treatment of coronary heart disease, viral myocarditis, chronic pulmonary heart disease, etc. In recent years, clinical and experimental studies successively reported the effect of Shenmai injection against doxorubicin cardiotoxicity. Its mechanism involves several aspects, including scavenging free radical, relieving calcium overload and protecting mitochondria. In addition, many studies have indicated that Shenmai injection can enhance the antitumor efficacy of radiotherapy or chemotherapy. It is suggested that Shenmai injection plays a vital role in the treatment of tumor, with the strengthening body resistance and eliminating evil Shenmai injection, which is derived from Shengmai san in Qianjin Yaofang, is widely used in the clinical treatment of coronary heart disease, viral myocarditis, chronic pulmonary heart disease, etc. In recent years, clinical and experimental studies successively reported the effect of Shenmai injection against doxorubicin cardiotoxicity. Its mechanism involves several aspects, including scavenging free radical, relieving calcium overload and protecting mitochondria. In addition, many studies have indicated that Shenmai injection can enhance the antitumor efficacy of radiotherapy or chemotherapy. It is suggested that Shenmai injection plays a vital role in the treatment of tumor, with the strengthening body resistance and eliminating evil efficacy, which mechanism is worthy of further explored.