基于析因设计的中药熏蒸治疗血热型银屑病研究

Clinical study on herbal steaming therapy in treating psoriasis of blood-heat type based on factorial design

关键词:  中药熏蒸疗法  临床应用研究  银屑病  析因设计

Key words:  herbal steaming therapy  clinical research  psoriasis  factorial design

摘要:

[目的] 通过析因设计探究中药熏蒸治疗血热型银屑病的临床疗效。[方法] 按两因素三水平的析因设计方法进行分析，两因素即温度组、时间组，三水平即温度组（38、40、42℃）、时间组（20、25、30 min），采集90例住院患者，随机分为9组进行试验，疗程均为2周。[结果] 不同温度、时间组合对中药熏蒸治疗血热型银屑病的疗效影响大小为：42℃×25 min > 42℃×30 min > 42℃×20 min > 40℃×25 min > 40℃×20 min > 38℃×30 min > 40℃×30 min > 38℃×20 min > 38℃×25 min。在时间与温度的交互作用统计分析结果中，提示时间、温度之间的交互作用无统计学意义（P>0.05），但就温度的单独效应结果来看，差异有统计学意义（P<0.05），即不同的温度对银屑病面积与严重性指数（PASI）评分下降值具有显著影响。进一步分析，42℃温度条件下对PASI评分降低影响更为显著。[结论] 中药熏蒸对血热型银屑病有良好的治疗效果，42℃×25 min组合的疗效明显优于其他组合，且无明显不良反应。

Abstract:

[Objective] To explore the clinical effects of herbal steaming therapy in treating blood-heat-type psoriasis based on factorial design.[Methods] Totally 90 patients were randomly divided into 9 groups to conduct a two-factor (temperature,time) three-level (temperature:38℃,40℃,42℃;time:20 min,25 min,30 min) factorial design.[Results] Combined the factor of temperature with time,there are different effect in treating blood-heat-type psoriasis with herbal steaming therapy:42℃×25 min > 42℃×30 min > 42℃×20 min > 40℃×25min > 40℃×20 min > 38℃×30 min > 40℃×30 min > 38℃×20 min > 38℃×25 min. The interaction of the statistical analysis results between time and temperature has no statistical significance (P>0.05). However,there is statistical significance (P<0.05) considering the single effect of temperature which means different value of temperature has remarkable influence on the decreasing PASI score. Furthermore,the PASI score decreases significantly when the temperature at 42℃.[Conclusion] In treating blood-heat-type psoriasis with herbal steaming therapy,the group of 42℃×25 min produces the highest curative effect and without any side effect.