加减秦艽牛蒡汤治疗湿热蕴肤型慢性荨麻疹及对血清IL-4，IgE和IFN-γ的影响

Effects of modified Qingeng Niuzang decoction on chronic urticaria with damp heat accumulation and its effects on serum IL-4, IgE and IFN-gamma

关键词:  慢性荨麻疹  秦艽牛蒡汤  湿热蕴肤型  炎症细胞因子

Key words:  chronic urticaria  Qingeng Niuzang decoction  damp heat accumulation skin type  inflammatory cytokines

摘要:

[目的] 观察加减秦艽牛蒡汤治疗湿热蕴肤型慢性荨麻疹的临床疗效及对血清白细胞介素4（IL-4），免疫球蛋白E （IgE）和干扰素γ（IFN-γ）的影响。[方法] 将90例慢性荨麻疹患者分为治疗组和对照组，每组45例。治疗组予加减秦艽牛蒡汤中草药口服；对照组给予氯雷他定10 mg，每日1次。治疗6周后观察症状总积分、血清IL-4，IgE和IFN-γ的变化，统计其临床疗效。[结果] 治疗6周后，治疗组症状、中医证候总积分明显低于对照组；血清IL-4和IgE水平低于对照组，IFN-γ高于对照组，比较差异均有统计学意义（P<0.05）。治疗组与对照组临床疗效总有效率分别为91.11%、71.11%，比较差异有统计学意义（P<0.05）。[结论] 加减秦艽牛蒡汤能明显改善慢性荨麻疹患者瘙痒、风团症状；可以降低血清IL-4，Ig E水平和提高血清IFN-γ水平。

Abstract:

[Objective] To observe the clinical effect of modified Qingeng Niuzang decoction on chronic urticaria of damp-heat skin type and its influence on serum interleukin-4(IL-4), immunoglobulin E(IgE)and interferon-gamma (IFN-gamma). [Methods] Ninety cases of chronic urticaria were divided into treatment group and control group, 45 cases in each group. The treatment group was given Qingeng Niuzang decoction and the control group was given loratadine 10 mg once a day. After 6 weeks of treatment, the total score of symptoms, the changes of serum IL-4, IgE and IFN-gamma were observed, and the clinical efficacy was statistically analyzed. [Results] After 6 weeks of treatment, the total scores of symptoms and TCM symptoms in the treatment group were significantly lower than those in the control group;the levels of serum IL-4 and Ig E were lower than those in the control group, and the levels of IFN-gamma were higher than those in the control group(P<0.05). The total effective rate of the treatment group and the control group were 91.11% and 71.11%, respectively. The difference was statistically significant (P <0.05). [Conclusion] Modified Qingeng Niuzang decoction can obviously improve itching and wind mass symptoms in patients with chronic urticaria, reduce serum IL-4, IgE levels and increase serum IFN-gamma levels.