| 摘要: |
| [目的]滋肾育胎丸对反复失败肾虚型体外受精-胚胎移植（IVF-ET）患者子宫内膜容受性的影响。[方法]观察60例肾虚型IVF-ET失败患者口服滋肾育胎丸前后临床症状的改善情况，其中36例患者在HCG的注射日子宫内膜厚度及类型、雌孕激素水平、子宫螺旋动脉搏动指数（PI）和阻力指数（RI），及其胚胎种植率与临床妊娠率的变化情况。[结果]服药后患者证候积分明显降低（P<0.01）；患者子宫内膜厚度明显增厚（P<0.01），子宫内膜类型A+B型明显增加（P<0.01）；患者血清雌孕激素水平变化无统计学意义，但雌激素/孕激素的数值较服药前降低（P>0.05）；患者子宫螺旋动脉PI及RI值明显下降，子宫动脉血流显著改善（P<0.01）；患者胚胎种植率和临床妊娠率有显著升高（P<0.05）。[结论]滋肾育胎丸改善反复失败肾虚型IVF-ET患者的子宫内膜容受性与临床症状，提高胚胎种植率和临床妊娠率。 |
| 关键词: 滋肾育胎丸 肾虚 子宫内膜容受性 体外受精-胚胎移植 |
| DOI：10.11656/j.issn.1673-9043.2019.04.14 |
| 分类号:R271.14 |
| 基金项目:罗元凯滋肾育胎丸中青年科研基金项目（140209）；国家中医药管理局国家中医临床研究基业地业务建设科研专项（JDZX2012038）；黑龙江中医药大学研究生创新科研项目（2019yjscx007）；中央高校基本科研业务费专项资金资助（项目资助编号：HIT.NSRIF.2020012）。 |
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| Effect of Zishen Yutai pill on endometrial receptivity in patients with repeated failure of kidney-deficiency type IVF-ET |
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LI Jia1, LIU Yichao2, YU Yang1, HAN Fengjuan3
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1.Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China;2.Harbin Institute of Technology Hospital, Harbin 150001, China;3.Department of Gynecology, First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150000, China
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| Abstract: |
| [Objective] To explore the effect of Zishen Yutai pill on endometrial receptivity in patients with repeated failure of kidney-deficiency type IVF-ET.[Methods] To observe the improvement of clinical Symptoms of 60 cases of kidney-deficiency IVF-ET failure patients before and after oral administration of Zishen Yutai pill, and the changes of endometrial thickness and type, estrogen and progesterone level, PI and RI of uterine spiral arteries, embryo implantation rate and clinical pregnancy rate of 36 patients on HCG injection day.[Results] After taking medicine, the symptom scores of patients were significantly decreased (P<0.01);patients with endometrial thickness increased significantly (P<0.01), type of endometrial A+B significantly increased (P<0.01);serum estrogen and progesterone levels in patients with no significant change, but the estrogen/progesterone values were lower than before treatment (P>0.05);patients with uterine spiral artery PI and RI values decreased significantly, uterine artery blood flow significantly improved (P<0.01);patient implantation rate and clinical pregnancy rate were significantly higher (P<0.05).[Conclusion] Zishen Yutai pill on endometrial receptivity and clinical symptoms in patients with repeated failure of kidney-deficiency type IVF-ET, and improve embryo implantation rate and clinical pregnancy rate. |
| Key words: Zishen Yutai pill kidney deficiency endometrial receptivity in vitro fertilization-embryo transfer |
