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| 蔓荆子中木脂素类成分的分离与结构鉴定 |
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黄艳丽1, 张晗1, 郭颖2, 李安平3, 姚进龙1, 邓雁如1, 房士明1
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1.天津中医药大学, 天津市中药化学与分析重点实验室, 天津 301617;2.天津南开医院, 天津 300100;3.瀚盟测试科技 (天津)有限公司, 天津 300457
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| 摘要: |
| [目的]对蔓荆子中的木脂素类成分进行研究。[方法]采用正相硅胶、Sephadex LH-20、MCI GEL（MCI）、反相ODS（ODS）等柱色谱及高效液相色谱手段进行分离纯化，并通过理化性质与波谱分析方法鉴定化合物的结构。[结果]从蔓荆子95%乙醇提取物中分离得到7个木脂素类单体成分，分别为dihydrodehydrodiconiferyl alcohol（1），ficusal（2），（7R，8S）-dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucopyranoside（3），dihydrodehydrodiconiferylalcohol-β-D-（2'-O-p-hydroxybenzoyl）glucoside（4），（7R，8R）-7，8-dihydro-9'-hydroxyl-3'-methoxyl-8-hydroxymethyl-7-（4-hydroxy-3-methoxyphenyl）-1'-benzofuranpropanol 9'-O-β-D-glucopyranoside（5），松脂醇（pinoresinol）（6），1-syringaresinol（7）。[结论]化合物5为首次从牡荆属中分离得到，化合物6和7为首次从该植物中分离得到的化合物。 |
| 关键词: 蔓荆子 木脂素 化学成分 结构鉴定 |
| DOI：10.11656/j.issn.1673-9043.2019.05.20 |
| 分类号:R284.1 |
| 基金项目:国家高技术研究发展计划（"863"计划）资助项目（2013AA093001）。 |
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| Isolation and structural identification of lignans from fruits of Vitex trifolia L. var. simplicifolia Cham. |
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HUANG Yanli1, ZHANG Han1, GUO Ying2, LI Anping3, YAO Jinlong1, DENG Yanru1, FANG Shiming1
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1.Tianjin University of Traditional Chinese Medicine, Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China;2.Tianjin Nankai Hospital, Tianjin 300100, China;3.Harmonia Testing(Tianjin) Co., Ltd, Tianjin 300457, China
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| Abstract: |
| [Objective] To study the lignans from the fruits of Vitex trifolia L. var. simplicifolia Cham.[Methods] The chemical compounds were isolated and purified by Silica gel column,Sephadex LH-20,MCI,ODS and PHPLC (Preparative high performance liquid chromatography,PHPLC) chromatorgraphies and identified by chemical and spectral analysis 1H,13C-NMR (Nuclear magnetic resonance,NMR),COSY (Correlation spectroscopy,COSY),HMQC (1H detected heteronuclear multiple quantum coherence,HSQC),HMBC (1H detected heteronuclear multiple bond correlation,HMBC) and MS (Mass spectrometer,MS).[Results] Seven lignan monomers were isolated from 95% ethanol extract of Vitex trifolia L. var. simplicifolia Cham. and identified as dihydrodehydrodiconiferyl alcohol (1), ficusal (2),(7R,8S)-dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucopyranoside (3),dihydrodehydrodiconiferyl alcohol-β-D-(2'-O-p-hydroxybenzoyl) glucoside (4),(7R,8R)-7,8-dihydro-9'-hydroxyl-3'-methoxyl-8-hydroxymethyl-7-(4-hydroxy-3-methoxyphenyl)-1'-benzofuranpropanol 9'-O-β-D-glucopyranoside (5),pinoresinol (6),1-syring-aresinol (7).[Conclusion] Compound 5 was obtained from Vitex genus firstly,and compounds 6,7 were isolated from the plant for the first time. |
| Key words: Vitex Fructus lignans chemical constituents structural identification |
