黄芩素对胰腺导管腺癌作用机制的研究进展

Research progress in the mechanism of baicalein on pancreatic ductal adenocarcinoma

关键词:  胰腺癌  中药  黄芩素

Key words:  pancreatic cancer  traditional Chinese medicine  baicalein

摘要:

胰腺癌是一种病死率极高的消化道恶性肿瘤，约90%为胰腺导管腺癌，和其他肿瘤一样，胰腺癌的侵袭转移是肿瘤患者死亡的主要原因。目前，由于临床上早期诊断困难，胰腺癌患者手术治疗的机率相较于其他消化道肿瘤低，化学治疗是继手术治疗后中晚期胰腺癌的主要治疗手段。由于化学治疗的不良反应逐渐增多，有必要寻求疗效好、毒副反应小的治疗方法和药物。中药以其药物来源广泛、临床应用历史悠久、多靶点协同作用等优点正成为抗肿瘤药物研究的热点。黄芩作为许多中药治疗胰腺癌的方剂配伍药材之一受到研究者的关注。黄芩素是主要来源于黄芩的黄酮类化合物，是目前证实的黄芩中具有抗炎、抗肿瘤活性的主要成分之一。文章对黄芩素在胰腺癌以及其他多种消化道肿瘤中抗肿瘤活性的研究现状及相关的作用及机制进行分析归纳，对黄芩、黄芩素的药物开发前景提出展望。

Abstract:

Pancreatic cancer is a kind of digestive tract cancer with high mortality,about 90% of which is pancreatic ductal adenocarcinoma. Like other cancers,the invasion and metastasis of pancreatic cancer is the main cause of death of cancer patients. At present,because of the difficulty in early diagnosis,the probability of surgical treatment of pancreatic cancer is lower than that of other digestive tract tumors. Chemical treatment is the main treatment after surgical treatment for advanced pancreatic cancer. As the side effects of chemotherapy are increasing,it is necessary to find a treatment method and drug with good effect and small side effects. Traditional Chinese medicine (TCM) has become a hot spot in the research of anti-tumor drugs because of its wide sources,long history of clinical application and multi-target synergistic effect. Scutellaria baicalensis Georgi,as one of the compatibility of many traditional Chinese medicine prescriptions for the treatment of pancreatic cancer,has attracted the attention of researchers. Scutellarin is a kind of flavonoid derived from Scutellaria baicalensis Georgi. It is one of the main components with anti-inflammatory and anti-tumor activities in Scutellaria baicalensis Georgi. In this paper,the anti-tumor activity of baicalein in pancreatic cancer and other digestive tract tumors was analyzed and summarized,and the prospect of drug development of Scutellaria baicalensis Georgi and baicalein was put forward.