基于数据挖掘探究中药古方治疗肺癌用药规律

Study on medication rules of Chinese herbal medicine ancient prescription in treatment of lung cancer based on data mining

关键词:  肺癌  中药古方  数据挖掘  聚类分析  关联规则  用药规律

Key words:  lung cancer  Chinese herbal medicine ancient prescription  data mining  clustering analysis  correlation analysis  medication regularity

摘要:

[目的] 基于数据挖掘技术探究中药古方治疗肺癌的用药规律。[方法] 以中国方剂数据库为检索库，检索治疗肺积或息贲的中药方剂，建立中药古方治疗肺癌方剂数据库，并采用Excel、SPSS 22.0及SPSS Modeler 14.0软件进行频数及频率分析、聚类分析、关联分析，进而对中药古方用药规律进行定量、定性分析。[结果] 中药古方治疗肺癌涉及方剂40首，中药110种，高频中药38味，甘草、人参、槟榔、木香等较为常用；温里药、补气药、理气药、止咳平喘药较常选用；核心药物聚类分析结果形成5个类别；经关联规则分析，支持度≥10%，得出药对关联规则21条，3味药配伍关联规则60条。[结论] 中药古方治疗肺癌以扶正祛邪为主要治则，多采用温阳益气，滋阴养血结合清热、化痰、止咳、解表、行气活血等方法选取相应中药组方治疗。

Abstract:

[Objective] Based on data mining technology to explore the medication rules of traditional Chinese medicine (TCM) ancient compound treatment of lung cancer.[Methods] Taking the Chinese prescription database as the retrieval database,searched the traditional Chinese medicine (TCM) ancient prescription for treating "Fei Ji" and "Xi Ben",established Chinese herbal ancient compound in the treatment of lung cancer prescription database,and used Excel,SPSS 22.0 and SPSS Modeler14.0 software for frequency and frequency analysis,cluster analysis and association analysis,and then the quantitative and qualitative analysis of the regularity of TCM ancient compound medication was conducted.[Results] Chinese herbal ancient compound treatment of lung cancer involves 40 prescriptions,110 kinds of Chinese medicine,38 flavors of high frequency herbs,Glycyrrhizae,Rhizoma ginseng,Semen arecae,Radix aucklandiae are commonly used;interior-warming,tonifying and regulating qi,and relieving cough and asthma drugs are most commonly used;the clustering analysis of core herbs showed 5 classifications;according to the analysis of association rules that the degree of support was>10%,the rules in pair herbs were 21,in 3 herbs were 60.[Conclusion] Medication regularity of traditional Chinese medicine in treating lung cancer is dominated by the method of reinforcing deficiency and reducing diarrhea,mostly use Wen yang Yi qi,nourishing yin and nourishing blood and clearing heat,phlegm,cough,solution table,row gas vitality and other methods for selecting the corresponding TCM prescription to treat the disease.