| 摘要: |
| [目的] 对岩五加（Tetrastigma obtectum）全植株进行植物化学研究，分离出2种新的吲哚类生物碱。[方法] 通过有机波谱解析鉴定结构，并以人乳腺癌细胞系MDA-MB-231为模型进行抗癌转移活性筛选。[结果] 分离得到2种新的吲哚类生物碱，分别为崖爬藤碱A（1）和崖爬藤碱B（2）。[结论] 在以人乳腺癌细胞系MDA-MB-231为模型进行抗癌转移活性筛选过程中，化合物1和2显示出阳性抗癌转移作用。 |
| 关键词: 岩五加 吲哚类生物碱 崖爬藤碱A和崖爬藤碱B 抗癌转移活性 分离 |
| DOI：10.11656/j.issn.1673-9043.2020.06.19 |
| 分类号:R284.2 |
| 基金项目: |
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| Isolatation of Antitumor metastasis indole alkaloids from Tetrastigma obtectum |
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ZHAO Jing1, SHI Guoru2, DUAN Hongquan2
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1.Tianjin Vocational College of Bioengineering, Tianjin 300462, China;2.School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
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| Abstract: |
| [Objective] Phytochemical investigation of the whole plant of Tetrastigma obtectumhas lead to the isolation of two new indole alkaloids.[Methods] Spectral analysis was used for identification. Compounds 1 and 2 were treated in the anti-tumor metastasis screening experiment in MDA-MB-231 cell lines.[Results] Two new indole alkaloids were found in Tetrastigma obtectum,named tetrastigmanine A (1) and B (2).[Conclusion] In the anti-tumor metastasis screening experiment in MDA-MB-231 cell lines,compounds 1 and 2 revealed positive effects on anti-tumor metastasis. |
| Key words: Tetrastigma obtectum indole alkaloid tetrastigmindole A and B antitumor metastasis effect isolate |
