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| 心力衰竭发生发展的自噬机制及中医药干预研究进展 |
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尹红伟1,2,3, 王慈1,2,3, 王帅1,2, 王贤良1,2, 侯雅竹1,2, 李晴1,2,3, 毛静远1,2
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1.天津中医药大学第一附属医院, 天津 300381;2.国家中医针灸临床医学研究中心, 天津 300381;3.天津中医药大学, 天津 301617
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| 摘要: |
| 近年来以自噬为切入点对心力衰竭机制的研究显示，自噬与心力衰竭的发生发展高度相关，中医药可通过干预多种自噬相关基因及信号通路，对心肌自噬水平进行调控，发挥抗心力衰竭作用。文章将对自噬在心力衰竭进程中发挥的作用、调控机制及中医药的干预作用进行综述。 |
| 关键词: 自噬 心力衰竭 机制 中医药 研究进展 |
| DOI：10.11656/j.issn.1673-9043.2021.06.02 |
| 分类号:R541.6 |
| 基金项目:国家自然科学基金青年基金项目（81904150）；教育部创新团队发展计划（IRT_16R54）；中医药传承与创新"百千万"人才工程（岐黄工程）岐黄学者。 |
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| Progress of autophagy mechanism and traditional chinese medicine intervention in heart failure |
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YIN Hongwei1,2,3, WANG Ci1,2,3, WANG Shuai1,2, WANG Xianliang1,2, HOU Yazhu1,2, LI Qing1,2,3, MAO Jingyuan1,2
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1.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China;2.National Clinical Research Center Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China;3.Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
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| Abstract: |
| In recent years,many researches have been carried out to explore the mechanism of heart failure with autophagy. More and more researches confirmed that autophagy is closely linked with the occurrence and progress of heart failure. Traditional Chinese medicine plays a role of resisting heart failure by intervening in a variety of autophagy-related genes and signaling pathways. The role of autophagy in the process of heart failure,regulatory mechanism and the intervention of traditional Chinese medicine will be reviewed in this paper. |
| Key words: autophagy heart failure mechanism traditional Chinese medicine research progress |
