基于数据挖掘法探讨黄文政教授治疗糖尿病肾病方药规律研究

Study on the prescription of Professor HUANG Wenzheng in the treatment of diabetic nephropathy based on data mining

关键词:  糖尿病肾病  数据挖掘  用药规律  黄文政

Key words:  diabetic nephropathy  data mining  dosing rules  HUANG Wenzheng

摘要:

[目的] 基于临床病例研究挖掘黄文政教授治疗糖尿病肾病（DN）的思路与用药规律。[方法] 收录黄文政教授门诊符合DN诊断标准的114首中药复方，建立黄文政教授治疗DN的中药数据库，运用SPSS24.0对其进行数据挖掘分析，对其临床治疗DN的药物进行频数分析、中药功效归类分析、聚类分析、关联规则分析以及用药规律进行探究，进一步指导临床运用。[结果] 获得114首方剂，中药147味，总用药频次达到1 822次，其中频数≥ 12次的药物共有43味，总的用药频次为1 475次，占总用药频次的80.9%。其中使用频次最高的前15味中药为生黄芪、丹参、鬼箭羽、萆薢、当归、山茱萸、熟地黄、土茯苓、汉防己、山药、肉桂、桃仁、白术、茯苓、炙甘草。关联规则分析得出黄文政教授治疗DN的常用药对。聚类统计分析共得出7组药物序列。[结论] 黄文政教授治疗DN时根据患者的不同病因病机、疾病分期、病程长短、疾病进展、患者体质等进行整体审察、辨证论治、对症用药。

Abstract:

[Objective] To explore the train of thought and medication rule of Professor HUANG Wenzheng in the treatment of diabetic nephropathy based on clinical case study.[Methods] Professor HUANG Wenzheng's outpatient clinic included 114 prescriptions of traditional Chinese medicine that met the diagnostic criteria of diabetic nephropathy. Professor HUANG Wenzheng's traditional Chinese medicine database for the treatment of diabetic nephropathy was established and analyzed by SPSS 24.0. The frequency analysis,efficacy classification analysis,cluster analysis and association rule analysis of the drugs used by Professor HUANG Wenzheng in clinical treatment of diabetic nephropathy were carried out. To explore the medication rule of Professor HUANG Wenzheng in the treatment of diabetic nephropathy in order to further guide the clinical application.[Results] The 114 prescriptions and 147 traditional Chinese medicines were obtained. the total drug frequency reached 1 822,of which there were 43 drugs with frequency ≥ 12,and the total drug frequency was 1 475,accounting for 80.9% of the total drug frequency. Among them,the first 15 herbs with the highest frequency of use are Radix Astragali,Radix Salviae Miltiorrhiza,Radix Castanopsis,Radix Angelicae Sinensis,Cornu Cervi Pantotrichum,Radix Rehmanniae,Poriae, Radix et Rhizoma Glycyrrhizae. According to the analysis of association rules,it is concluded that Professor HUANG Wenzheng's commonly used drugs in the treatment of diabetic nephropathy. The 7 groups of drug sequences were obtained by cluster statistical analysis.[Conclusion] Professor HUANG Wenzheng carried out overall examination, syndrome differentiation and treatment, and symptomatic medication according to the different etiology and pathogenesis, disease stage,course of disease,disease progression and patient physique in the treatment of diabetic nephropathy.