基于数据挖掘探讨中药治疗后循环缺血性眩晕的用药规律

Study on medication rule of Chinese medicine in treating posterior circulation ischemic vertigo based on data mining

关键词:  数据挖掘  后循环缺血性眩晕  用药规律

Key words:  data mining  posterior circulation ischemia vertigo  medication regularity

摘要:

[目的] 运用数据挖掘技术探讨中医药治疗后循环缺血性眩晕的用药规律。[方法] 检索2004—2019年治疗后循环缺血性眩晕的相关文献，根据纳入标准和排除标准选择符合要求的文献，将处方内容记录到数据库中，通过SPSS 25.0和IBM SPSS Modeler 18软件分析用药频率、频数及关联性，揭示治疗后循环缺血性眩晕的用药规律。[结果] 筛选出相关文献186篇，纳入治疗后循环缺血性眩晕处方210首，涉及中药种类173味，使用频数2 302次，其中天麻、川芎和半夏的使用频率最高。药物类别以补虚药、活血化瘀药、息风止痉药、平肝潜阳药、解表药、利湿药为主。证型分布前3位依次为气血亏虚型、瘀血阻窍型、风痰上扰型。采用Apriori算法进行关联分析，支持度≥10%时支持度前10位的药对基本以补虚药、平肝潜阳药、息风止痉药、活血化瘀药及解表药为主。[结论] 中医药治疗后循环缺血性眩晕以补虚药最为多见，其次是平肝潜阳药、息风止痉药、活血化瘀药、解表药，药组与药对基本上是补虚药、平肝潜阳药、息风止痉药、行气药、利水消肿药、解表药及活血化瘀药的不同组合，证型与用药方面关系密切。虚损是根本原因，风、痰、瘀为标，应以补虚泻实为原则，权衡标本缓急。

Abstract:

[Objective] To explore the rule of using traditional Chinese medicine(TCM) to treat patients with vertigo caused by posterior circulation Ischemia by data mining technique.[Methods] By Literature Search, we collected the related clinical literature from 2004 to 2019, and selected the literature according to the inclusion and exclusion criteria. The prescription contents were recorded in the database, analyze the frequency, frequency analysis and relevance through SPSS 25.0 and IBM SPSS Modeler 18 software, and reveal the medication rule of the circulation ischemic vertigo after treatment.[Results] We screened out 186 related studies, 210 prescriptions of circulation ischemia vertigo were included in the compound prescription of traditional Chinese medicine, involving 173 herbs, and the frequency of use was 2 302 times. Among them, Rhizoma Gastrodiae, Rhizoma Ligusticum Chuanxiong, and Rhizoma Pinelliae are used most frequently. The main drugs are tonifying drugs, blood-activating and stasis-removing drugs, relieving spasm by calming endogenous wind, pacifying liver and subduing yang drugs, exterior-releasing drugs and damp-excreting drugs. The top three syndrome types were deficiency of both qi and blood, syndrome of static blood blocking orifices, syndrome of wind-phlegm invading upward. Apriori algorithm was used for association rules, with support degree ≥ 10%. The top 10 combinations of drug pairs were selected, mainly including tonic drugs, pacifying liver and subduing yang drugs, relieving spasm by calming endogenous wind drugs, blood-activating and stasis-removing drugs, exterior-releasing drugs.[Conclusion] The therapeutic effect of traditional Chinese medicine on posterior circulation ischemia vertigo is significant, and the most prominent rule is tonifying drugs, and the other effects of the herbs for relieving exterior symptoms are the main application, followed by drugs for pacifying liver and subdue yang drugs, extinguishing wind and stopping convulsions drugs, blood-activating and stasis-resolving drugs, and exterior-releasing drugs. The drug group and the drug pair are basically different combinations of drugs for tonifying drugs, acifying liver and subdue yang drugs, extinguishing wind and stopping convulsions drugs, qi-moving drugs, edema-alleviating diuretic, exterior-releasing drugs, blood-activating and stasis-resolving drugs. Syndrome type is closely related to medication. Deficiency is the root cause. Wind, phlegm and blood stasis are the criteria. The principle of tonifying deficiency and reducing diarrhea should be taken to balance the urgency of the specimen.