基于聚类分析和关联分析的单纯性肥胖的中药用药规律研究

Study on the regularity of traditional Chinese medicine for simple obesity based on cluster analysis and association analysis

关键词:  单纯性肥胖  中医药  用药规律  聚类分析  关联分析

Key words:  simple obesity  traditional Chinese medicine  regularity of traditional Chinese medicine  cluster analysis  association analysis

摘要:

[目的] 基于聚类分析和关联分析探讨单纯性肥胖的中药用药规律, 为临床用药提供参考。[方法] 检索中国期刊全文数据库(CNKI)、维普中文科技期刊数据库、万方数据库、中国生物医学文献数据库, 筛选建库至2019年12月间符合纳入排除标准的中药治疗单纯性肥胖的文献, 对纳入文献进行资料提取, 采用Excel 2010软件建立数据库。使用Excel2010、SPSS Statistics 25.0和SPSS Modeler 18.0软件分析其用药规律。[结果] 共计纳入文献88篇, 收集方剂103首, 涉及药物146味, 总计用药频次1 008次。其中出现频率较高的10味中药为茯苓、白术、泽泻、山楂、甘草、大黄、陈皮、决明子、荷叶和半夏。治疗单纯性肥胖的常用药物种类为补虚药、利水渗湿药、清热药、理气药、消食药。治疗药物中出现频率较高的药味为甘、苦、辛味, 药性以温性者最多, 归经以入脾经者最多。对用药进行聚类分析和关联分析, 挖掘出强关联药对8对, 角药10个, 4味药组5个, 治疗单纯性肥胖的基本方3个。[结论] 单纯性肥胖用药以补气、利湿、健脾为主, 兼以清热和理气, 研究结果可为临床治疗提供辅助借鉴。

Abstract:

[Objective] To analyze the regularity of traditional Chinese medicine for simple obesity on the basis of cluster analysis and association analysis in order to provide reference for clinical medication.[Methods] Through China National Knowledge Internet(CNKI), Wanfang Database, Vip Database and China Biomedical Literature Database, we screened the literatures of Chinese medicine treatment of simple obesity that met the inclusion criteria from the establishment of the database to December 2019, extracted the data of the included literatures, and established the database by using Excel 2010. Excel 2010, SPSS statistics 25.0 and SPSS modeler 18.0 were used to analyze the medication rule.[Results] The 88 references were included, involving 103 Chinese medicinal decoctions and 146 kinds of Chinese herbs which herbs frequency reached 1008. 10 Chinese herbs with high frequency are Poria cocos, Atractylodes macrocephala, Alisma orientalis, Hawthorn, Licorice, Rhubarb, Dried tangerine peel, Cassia seed, Lotus leaf and Pinellia ternata. The types of commonly used Chinese herbs are tonic herbs, damp-draining diuretic herbs, heat-clearing herbs, qi-regulating herbs and digestant herbs. The top 3 most often used kinds of flavors are sweet, bitter and sim. The mild property is the most common property. Spleen is the most common channel tropism. Association analysis showed 8 strongly related herb pairs, 10 strongly related combinations of 3 kinds of herbs and 5 strongly related combinations of 4 kinds of herbs.Cluster analysis showed 3 prescriptions.[Conclusion] The main medication strategy is tonifying qi, removing dampness and invigorating the spleen, with some of heat-clearing and qi-regulating.The results can be used for reference in clinical treatment.