开心散治疗阿尔茨海默病的研究进展

Research progress of Kaixin Powder treating Alzheimer's disease

关键词:  开心散  阿尔兹海默病  处方考证  入血成分  药理作用

Key words:  Kaixin Powder  Alzheimer's disease  prescription research  ingredients into the blood  pharmacological action

摘要:

开心散(KXS)源自唐代古籍《备急千金药方》, 组方中包含人参、茯苓、石菖蒲、远志4味药材, 该方与其类方在神经系统疾病中发挥着重要作用。KXS凭借其益气开窍之功效, 对神经退行性疾病方面的研究不断增加和深入。近年来, 阿尔茨海默病(AD)发病率呈逐年上升趋势, 成为中国重大公共卫生问题, 其预防与治疗成为关注重点。通过对前期相关文献整理归纳, 本文将围绕古方KXS的处方考证、入血成分、药理作用3个层面展开综述, 以期明确KXS在治疗AD方面的起效成分和影响的药理学指标, 为后期新药开发提供理论支持。

Abstract:

Kaixin Powder is a famous classical prescription that was derived from Tang Dynasty ancient book named Important Prescription Worth a Thousand Gold for Emergency. Kaixin Powder is composed of Panax ginseng, Poria cocos, Acori Tatarinowii Rhizoma, and Polygala tenuifolia. This formula and its associated prescriptions play an important role in treating nervous system disease. The research on neurodegenerative diseases' therapy attracts more and more attention because of its effect of benefiting qi for resuscitation. In recent years, the incidence rate of Alzheimer's disease(AD) shows an increasing trend year by year, and has become a major public health problem. Therefore, its prevention and treatment become the focus of attention. Through summarizing the relevant literatures in the earlier stage, this paper will review the prescription research, ingredients into the blood, and pharmacological effect of Kaixin Powder, in order to clarify the active components and pharmacological indexes of Kaixin Powder in the treatment of AD, and provide theoretical support for the later development of new drugs.