淫羊藿苷治疗骨质疏松的相关通路研究进展

Advances in research on related pathways of icariin in the treatment of osteoporosis

关键词:  骨质疏松  淫羊藿苷  信号通路

Key words:  osteoporosis  icariin  signal pathway

摘要:

骨质疏松是一种以骨量减少、骨脆性增加、骨组织微结构破坏为特点的全身性代谢性疾病, 发病人群主要为中老年人。淫羊藿苷作为中药淫羊藿的主要活性成分, 可以通过多种通路抑制破骨细胞, 激活成骨细胞, 调节骨髓间充质干细胞分化, 从而治疗骨质疏松。文章从Wnt/β-catenin通路、OPG/RANK/RANKL通路、MAPK通路、Notch通路、Hedgehog通路、BMP/Smads通路、PI3K/Akt通路、PPAR-γ通路、cAMP/PKA通路等淫羊藿苷治疗骨质疏松的相关通路做一篇综述, 以期为淫羊藿苷治疗骨质疏松的进一步开发提供思路。

Abstract:

Osteoporosis is a systemic metabolic disease characterized by decreased bone mass, increased bone fragility, and bone tissue microstructure destruction. The main affected population is middle-aged and elderly people. There is no term for osteoporosis in Chinese medicine, but according to clinical symptoms, it is classified into categories such as "bone atrophy", "bone paralysis", and "Bone dry". In Chinese medicine, the kidney governs the bone and produces marrow. Epimedium is a traditional Chinese medicine for invigorating the kidney. It has the effects of invigorating the kidney and strengthening yang, strengthening the muscles and bones, dispelling wind and removing dampness, etc. Icariin is the main active ingredient. This article summarizes the related pathways of icariin in the treatment of osteoporosis such as Wnt/β-catenin pathway, OPG/RANK/RANKL pathway, MAPK pathway, Notch pathway, Hedgehog pathway, BMP/Smads pathway, PI3K/Akt pathway, PPAR-γ pathway, cAMP/PKA pathway etc, in order to provide idea as for the further development of icariin in the treatment of osteoporosis.