| 摘要: |
| 复发性流产（RSA）病因复杂，半数以上患者都未能查明发病的具体原因，被称为不明原因的RSA（URSA），且大多被认为与免疫失衡有关。近年来发现，T淋巴细胞及其亚群与RSA之间密切相关，但其导致免疫失衡的致病机制尚不完全明确，故文章对RSA疾病中T淋巴细胞变化的研究进展进行综述，探讨母胎界面免疫细胞失衡与RSA的关系。 |
| 关键词: 复发性流产 T淋巴细胞 免疫机制 |
| DOI：10.11656/j.issn.1673-9043.2022.05.22 |
| 分类号:R714.21 |
| 基金项目:陕西省咸阳市科学技术局项目（2018K02-96）；陕西省教育厅专项科研计划项目（17JK0212）。 |
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| Research progress of T lymphocytes and their subsets in patients with recurrent spontaneous abortion |
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YU Tian1, SHU Hongying2, YANG Xiaoqi2
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1.College of Second Clinical Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, China;2.The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China
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| Abstract: |
| Recurrent spontaneous abortion(RSA) is a complicated and heterogeneous disease and more than half of the patients have failed to find out the exact cause of the disease, known as unexplained recurrent abortion (URSA), which is thought to be due to immunological mechanisms probably. In recent years, it has been found that T lymphocytes and their subsets are closely related to RSA. However, the mechanisms of immunologic imbalance are unknown. Here, we will review the changes of T-cells in RSA, so as to explore the relationship between the imbalance of immune cells at maternal-fetal interface and RSA. |
| Key words: recurrent spontaneous abortion T lymphocytes immune mechanism |
