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| 中药活性成分对肿瘤细胞周期基因的调控作用 |
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申倩1, 沈雨蕾2, 曾雪倩3, 李俊辰4, 张建岭4, 庞博1
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1.中国中医科学院广安门医院, 北京 100053;2.北京中医药大学, 北京 100029;3.上海中医药大学, 上海 201203;4.天津中医药大学, 天津 301617
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| 摘要: |
| 细胞周期基因异常表达是肿瘤细胞携带缺陷基因无限增殖的关键，是具有巨大潜力的临床治疗靶点。中药活性成分因其抗癌效果显著，不良反应少等优点而被广泛关注。研究显示有中药活性成分可调控Cyclin、CDK和CKI等基因表达，而抑制肿瘤细胞生长，诱导细胞凋亡。本研究旨在为中药活性成分抗癌治疗的进一步临床应用提供药效基因分子生物学基础。 |
| 关键词: 中药 活性成分 肿瘤 细胞周期 基因调控 |
| DOI：10.11656/j.issn.1673-9043.2022.06.22 |
| 分类号:R285 |
| 基金项目: |
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| Regulatory effect of active components of traditional Chinese medicine on tumor cell cycle genes |
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SHEN Qian1, SHEN Yulei2, ZENG Xueqian3, LI Junchen4, ZHANG Jianling4, PANG Bo1
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1.Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;2.Beijing University of Traditional Chinese Medicine, Beijing 100029, China;3.Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;4.Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
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| Abstract: |
| The abnormal expressions of cell genes are the key gene group for tumor cells carrying defective genes for unlimited proliferation,and they are the clinical targets with great potential. The active components of traditional Chinese medicine are widely concerned because of their remarkable anticancer effect and few adverse reactions. It has been shown that the active components of traditional Chinese medicine can regulate the expressions of Cyclin, CDK and CKI,and inhibit the growth of tumor cells and induce apoptosis. In-depth research can provide molecular biological basis of pharmacodynamic genes for anticancer treatment with traditional Chinese medicine and further clinical application of the active components. |
| Key words: traditional Chinese medicine active component tumor cell cycle gene regulation |
