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| 糖尿病心力衰竭中的血管新生作用——中医药治疗糖尿病心肌病的潜在靶点 |
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陈子豪1,2, 贺爽1,2, 赵芳哲1,2, 范斯文1,2, 张雷1,2, 杨鑫月1,2, 李珊1,2, 朱彦1,2
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1.天津中医药大学, 组分中药国家重点实验室, 天津 301617;2.天津国际生物医药联合研究院, 中药新药研发中心, 天津 300457
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| 摘要: |
| 临床上有充分证据表明，糖尿病与心力衰竭风险升高密切相关。糖尿病会加重心肌梗死后的舒张和收缩性心力衰竭，引发特异性心肌微血管并发症，即糖尿病心肌病。生物医学的新进展揭示了糖尿病与心血管异常之间的复杂联系及作用机制，包括能量代谢、血糖控制和血管生成等。基于整体观和辨证论治理论的中医药在糖尿病及其并发症的治疗上有着悠久的历史。文章采用生物反应信号网络分析，发现通过调节血管生成治疗糖尿病心力衰竭的潜在治疗靶点，并对一些治疗糖尿病、心力衰竭的常用中药相关基础研究进行总结，发现这些药物是治疗糖尿病心力衰竭中成药的重要组成，且活性成分可以作用于生物反应信号网络分析出的部分潜在治疗靶点，以此来阐述中药通过调节血管生成治疗糖尿病心力衰竭的可行性，为临床参考应用提供了一定证据支持。 |
| 关键词: 糖尿病心肌病 心力衰竭 血管新生 中药 活血化瘀 药物疗法 |
| DOI：10.11656/j.issn.1673-9043.2023.01.21 |
| 分类号:R587.2 |
| 基金项目:国家自然科学基金项目（81873037）；国家重点研发计划项目（2018YFC1704502）；国家科技重大专项项目（2018ZX01031301）。 |
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| The role of angiogenesis in diabetic heart failure:a potential target for Chinese medicine in the treatment of diabetic cardiomyopathy |
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CHEN Zihao1,2, HE Shuang1,2, ZHAO Fangzhe1,2, FAN Siwen1,2, ZHANG Lei1,2, YANG Xinyue1,2, LI Shan1,2, ZHU Yan1,2
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1.Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Component Chinese Medicines, Tianjin 301617, China;2.Tianjin International Joint Institute of Biomedicine, Center for New Drug Development in Traditional Chinese Medicine, Tianjin 300457, China
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| Abstract: |
| There is strong clinical evidence that diabetes mellitus is closely associated with an increased risk of heart failure. Diabetes exacerbates diastolic and systolic heart failure after myocardial infarction,triggers an idiosyncratic myocardial microvascular complication,diabetic cardiomyopathy. New advances in biomedicine have revealed complex links and mechanisms of action between diabetes and cardiovascular abnormalities,including energy metabolism,glycaemic control and angiogenesis. Traditional Chinese medicine(TCM),based on a holistic view and dialectical theory of treatment,has a long history in the management of diabetes and its complications. This review uses bioresponse signalling network analysis to identify potential therapeutic targets for the treatment of diabetic heart failure through modulation of angiogenesis,and summarises some basic research related to TCM commonly used in the treatment of diabetes and heart failure. These drugs were found to be important components of proprietary TCM for the treatment of diabetic heart failure,and the active ingredients could act on some of the potential therapeutic targets identified by the bioresponse signalling network analysis,thus illustrating the feasibility of TCM for the treatment of diabetic heart failure through modulation of angiogenesis and providing some evidence to support the clinical reference application. |
| Key words: diabetic cardiomyopathy heart failure angiogenesis traditional Chinese medicine blood activation pharmacotherapy |
