慢性肾脏病肠道菌群-代谢网络及中医药应用研究进展

Research progress in the gut microbiota-metabolic network of chronic kidney disease and application of traditional Chinese medicine

关键词:  慢性肾脏疾病  肾肠轴  肠道菌群  代谢  治法用药

Key words:  chronic kidney disease  renal-intestinal axis  gut microbiota  metabolite  treatment and medication

摘要:

近年来，肠道菌群及其衍生代谢物在慢性肾脏疾病（CKD）中的研究不断深入，以此为干预靶标的中医药治疗策略对延缓CKD进展具有较大应用前景。文章首先介绍了CKD的肠道微生态现状，然后基于肾肠轴深入探讨CKD肠道菌群-代谢网络致病原理，最后立足经典中医理论指导下的治疗理念及现代药理研究总结中医药干预CKD肠道菌群-代谢网络的具体治法用药，旨在进一步明确以肠道菌群及其代谢物为作用靶点的中医药干预在CKD中的应用价值。

Abstract:

In recent years,the gut microbiota and derived metabolites of chronic kidney disease(CKD) have been widely studied,and traditional Chinese medicine(TCM) treatment methods based on this as an intervention target have great application value in delaying the development of CKD. In this paper,we firstly introduced the current status of intestinal microecology in CKD. Then,we discussed the pathogenic principles of gut microbiota and derived metabolites network in CKD based on the renal-intestinal axis. Finally,based on the treatment concept under the guidance of classical Chinese medicine theory and modern pharmacological research,the specific treatment and medication of TCM intervention in the gut microbiota-metabolic network of CKD were summarized,aiming to further clarify the application value of TCM intervention in CKD by targeting the gut microbiota and their metabolites.