复方丹参滴丸联合西医常规治疗冠心病心绞痛的回顾性队列研究

Retrospective cohort study of Compound Danshen Dropping Pills combined with Western medicine in the treatment of coronary heart disease and angina pectoris

关键词:  冠心病心绞痛  复方丹参滴丸  回顾性  队列研究

Key words:  coronary heart disease angina pectoris  Compound Danshen Dropping Pill  retrospective  cohort study

摘要:

[目的] 观察复方丹参滴丸联合西医常规治疗冠心病心绞痛的临床疗效，分析其临床疗效优势。[方法] 采用回顾性队列研究方法， 收集天津市 6 家医院病案管理系统中的冠心病心绞痛患者， 采集时间为 2014 年 1 月—2022 年 6 月。将这些患者分为暴露组和非暴露组，暴露组使用复方丹参滴丸联合西医常规治疗，非暴露组单独使用西医常规治疗，两组按照 1∶1 比例进行匹配，每组各 612 例。观察两组患者住院期间心血管事件发生率、临床生化指标及颈部血管彩超。[结果] 暴露组谷草转氨酶、乳酸脱氢酶、C 反应蛋白、凝血酶时间、D-二聚体、血糖、糖化血红蛋白、肌酐、尿酸、谷丙转氨酶、总胆红素、白细胞计数、颈动脉内中膜厚度、颈动脉斑块检出率低于非暴露组，差异具有统计学意义（P<0.05）。[结论] 复方丹参滴丸联合西医常规治疗的冠心病心绞痛患者心血管事件发生率较低，凝血功能、肾功能、肝功能、血糖、血脂水平较稳定，颈动脉内中膜厚度较小，斑块发生率较低。

Abstract:

[Objective] To observe the clinical efficacy of Compound Danshen Dropping Pills combined with conventional western medicine treatment of coronary heart disease and angina pectoris，and analyse its clinical efficacy advantages. [Methods] A retrospective cohort study，coronary heart disease and angina pectoris patients from the medical record management system of 6 hospitals in Tianjin were collected from January 2014 to June 2022. The patients were divided into exposed and non-exposed groups，the exposed group was treated with Compound Danshen Dropping Pills combined with conventional western medicine treatment，and the non-exposed group was treated with conventional western medicine treatment. The two groups were matched in a 1∶1 ratio，with 612 cases each. Observe cardiovascular events，clinical biochemical indicators and carotid artery ultrasound indices in both groups during hospitalization. [Results] Aspartate aminotransferase，lactate dehydrogenase，C reactive protein， thrombin time，D-dimer，blood glucose，glycated hemoglobin，creatinine，uric acid，alanine aminotransferase，total bilirubin，leukocyte count，carotid intima-media thickness，and carotid plaque in the exposed group were significantly lower than those of the non-exposed group，and the differences was statistically significant （P<0.05）. [Conclusion] It showed that the patients with coronary heart disease and angina pectoris treated with Compound Danshen Dropping Pills and conventional western medicine treatment have lower incidence of cardiovascular events，coagulation function，renal function，liver function，blood glucose and blood lipid levels were relatively stable，carotid middle thickness was smaller，and lower incidence of plaques.