电针联合中药外敷治疗特发性面神经麻痹的临床疗效观察

Observation on the clinical efficacy of electroacupuncture combined with external application of traditional Chinese medicine in the treatment of Idiopathic facial nerve paralysis

关键词:  电针  中药外敷  特发性面神经麻痹  随机对照试验

Key words:  electroacupuncture  external application of traditional Chinese medicine  idiopathic facial nerve paralysis  randomized controlled trial

摘要:

[目的] 评价电针联合中药外敷治疗特发性面神经麻痹的临床疗效和安全性。[方法] 符合纳入与排除标准的 180 名特发性面神经麻痹患者按 1∶1∶1 比例被随机分为治疗 1 组、治疗 2 组和对照组，治疗 1 组采用电针治疗，治疗 2 组采用电针联合中药外敷治疗，对照组采用西药口服治疗，3 组患者均接受 3 周的治疗。主要结局指标为Sunnybrook 面部分级系统（SFGS）评分，次要结局指标为 House-Brackmann 分级量表（HBGS）评分，NottinghamSystem 评分和不良事件发生率。[结果] 164 人完成了 3 周的治疗，其中治疗 1 组 56 例，治疗 2 组 53 例，对照组 55 例，3 组患者的基线特征一致。治疗 3 周后，3 组患者的 SFGS 评分、HBGS 评分和 Nottingham System 评分均优于治疗前（P<0.01），且治疗 2 组的各评分优于治疗 1 组和对照组（P<0.05），差异均具有统计学意义；研究过程中 3 组患者均未出现不良反应。[结论] 电针联合中药外敷是一种安全有效的特发性面神经麻痹治疗方案，可以促进面神经功能的恢复，为进一步改善特发性面瘫患者的预后提供了新的治疗思路。

Abstract:

[Objective] This study aims to evaluate the clinical efficacy of electroacupuncture combined with external application of traditional Chinese medicine （EATCM） in the treatment of idiopathic facial nerve paralysis. [Methods] 180 patients with idiopathic facial nerve paralysis who met the inclusion and exclusion criteria were randomly divided into treatment group 1，treatment group 2 and control group according to the ratio of 1 ∶1 ∶1. Treatment group 1 was treated with electroacupuncture，treatment group 2 was treated with electroacupuncture combined with EATCM，and control group was treated with oral Western medicine. All three groups received 3 weeks of treatment. The primary outcome measure was the Sunnybrook Facial Grading System（SFGS） score，and the secondary outcome measures were the House-Brackmann Grading Scale （HBGS），Nottingham System score，and incidence of treatment-related adverse events （TRAEs）. [Results] 164 patients completed 3 weeks of treatment， including 56 patients in treatment group 1，53 patients in treatment group 2，and 55 patients in the control group. The baseline characteristics of the three groups were consistent （P>0.05）. After 3 weeks of treatment，the SFGS score，HBGS and Nottingham System score of the three groups were better than those before treatment（P<0.05），and the scores of the treatment group 2 were significantly better than those of the treatment group 1 and the control group （P<0.05）；There was no adverse reactions in the three groups during the study. [Conclusion] Electroacupuncture combined with EATCM is a safe and effective treatment for idiopathic facial nerve paralysis，which can significantly promote the recovery of facial nerve function and provide a new therapeutic idea for further improving the prognosis of patients with idiopathic facial paralysis.