现代与传承：STING激动剂的双重视角

Modernity and heritage：a dual perspective on STING agonists

关键词:  STING激动剂  中药类STING激动剂  cGAS-STING信号通路

Key words:  stimulator of interferon genes agonist  traditional Chinese medicine-derived sting agonists  cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway

摘要:

cGAS-STING信号通路是免疫系统中的关键调节因子，对肿瘤免疫治疗具有重要的研究和应用前景。该信号通路激活STING蛋白后，能够促进I型干扰素（IFN-I）的产生，并进一步影响树突细胞的成熟，增强T淋巴细胞和自然杀伤（NK）细胞的攻击力，从而连接先天免疫和适应性免疫反应。文章重点回顾了化学类STING激动剂以及中药成分对cGAS-STING信号通路的调节作用。这些研究不仅揭示了STING激动剂的分子机制，而且为开发新型免疫调节剂提供了理论基础。此外，文章还探讨了中药成分与现代药物设计的结合潜力，为未来免疫治疗的研究提供了新的视角和策略。

Abstract:

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING) signaling pathway is a pivotal regulator within the immune system and holds significant potential for research and application in cancer immunotherapy. Upon activation of the STING protein by this pathway,it promotes the production of Type I interferons,which subsequently affects the maturation of dendritic cells and enhances the cytotoxic capabilities of T lymphocytes and natural killer cells,thereby bridging innate and adaptive immune responses. This review focuses on the regulatory effects of chemical STING agonists and the modulation of the cGAS-STING signaling pathway by components derived from traditional Chinese medicine(TCM). These studies not only elucidate the molecular mechanisms of STING agonists but also provide a theoretical foundation for the development of novel immunomodulatory agents. Furthermore,this review discusses the potential integration of TCM components with modern drug design,offering new perspectives and strategies for future research in immunotherapy.