基于文献数据挖掘探析针药结合治疗肺炎的临床优势及选穴规律

Analysis on clinical advantages and acupoint selection rules of acupuncture combined with medicine in the treatment of pneumonia based on data mining

关键词:  肺炎  针药结合  数据挖掘  临床优势  选穴规则

Key words:  pneumonia  acupuncture combined with medicine  data mining  clinical advantages  acupoint selection rules

摘要:

[目的] 总结针药结合治疗肺炎的临床优势和选穴规则，探析针药结合优效治疗方案。[方法] 检索近20年收录在中国知网、万方、维普、中国生物医学文献数据库、PubMed、Embase、Web of Science、Scopus的中文及英文文献，建立针药结合治疗肺炎临床数据库，使用频数统计、SPSS 18.0及Gephi0.10对研究的关系信息开展分析。[结果] 针药结合以改善肺炎患者相关炎性因子指标为主。针灸干预方法以手针为主，使用频次较高的5个腧穴为足三里、列缺、肺俞、三阴交、丰隆，归经以手太阴肺经为主，特定穴多为五输穴和原穴；关联规则分析提示，相关性最高的腧穴组合为足三里-三阴交，其次为足三里-曲池；通过复杂网络k-core层次分析和社团分析得到28个核心腧穴及2类核心腧穴社团；腧穴重要程度分析排名前6的腧穴包括合谷、列缺、曲池、三阴交、中府、足三里。[结论] 针药结合治疗肺炎的临床优势在抑制全身炎性反应，选穴以手太阴肺经为主，核心腧穴处方包括合谷、列缺、曲池、三阴交、中府、足三里、肺俞、丰隆。

Abstract:

[Objective] To summarize the clinical advantages and acupoint selection rules of acupuncture combined with medicine for the treatment of pneumonia and to explore the optimal treatment plans.[Methods] Clinical research literatures from 2003 to 2023 AD was retrieved from CNKI,Wanfang,VIP,SinoMed,PubMed,Embase,Web of Science and Scopus databases. Excel 2021 was used to create a database and to carry out acupoint frequency analysis. Association rule analysis was performed using SPSS Modeler 18.0,Gephi 0.10 was used to construct the model and perform complex network analysis.[Results] Acupuncture combined with medicine for the treatment of pneumonia primarily aims to improve the patient's related inflammatory markers. Traditional acupuncture was the primary intervention. The acupoints used with highest frequency were:Zusanli(ST36),Lieque(LU7),Feishu(BL13),Sanyinjiao(SP6) and Fenglong(ST40). The main meridian was the lung meridian,and the specific acupoints were mostly selected from "Wushu" point and "Yuan" point. The association rule showed that the acupoints combination with the highest correlation was Zusanli(ST36)-Sanyinjiao(SP6),followed by Zusanli(ST36)- Quchi(LI11);the 28 core acupoints and 2 types of core acupoint associations were obtained by complex network k-core hierarchical analysis and association analysis. According to the analysis of the importance of acupoints,the top 6 acupoints were Hegu(LI4),Lieque(LU7),Quchi(LI11),Sanyinjiao(SP6),Zhongfu(LU1),and Zusanli(ST36).[Conclusion] The clinical advantage of combining acupuncture with medication in treating pneumonia lies in suppressing systemic inflammatory responses. The selection of acupoints primarily focuses on the lung meridian,with core acupoint prescriptions including Hegu(LI4),Lieque(LU7),Quchi(LI11),Sanyinjiao(SP6),Zhongfu(LU1),Zusanli(ST36),Feishu(BL13) and Fenglong(ST40).