芳香开窍药调节脑卒中血脑屏障的作用机制

Mechanism of aromatic resuscitation herbs on blood brain barrier regulation in stroke

关键词:  芳香开窍药  血脑屏障  卒中

Key words:  aromatic resuscitation herbs  blood-brain barrier  stroke

摘要:

卒中是一种急性神经系统疾病，是全球死亡和长期残疾的主要原因之一。卒中发生后血脑屏障会受到破坏，继而出现脑损伤、神经损伤以及增加出血风险等严重后果。芳香开窍药在治疗卒中方面已经有数千年的历史，能够发挥其药物轻灵、作用趋向为升浮的特性以达到开窍醒脑的作用。现代研究发现芳香开窍药不仅能够恢复受损后的血脑屏障通透性，同时能够促进药物通过血脑屏障进入脑内发挥作用，主要涉及的机制为调控紧密连接蛋白和神经递质的表达、作用于转运蛋白和调节炎症反应等。故文章综述芳香开窍药调节卒中后血脑屏障的机制以及开窍药结合现代新型制剂的开发。

Abstract:

Stroke is an acute diseases of the nervous system,is the world's one of the leading causes of death and long-term disability. After stroke,the blood-brain barrier will be damaged,followed by brain damage,nerve damage,and increased risk of bleeding and other serious consequences. Aromatic resuscitation herbs have a history of thousands of years in the treatment of stroke,which can play the characteristics of light and buoyance of drugs to achieve the role of resuscitating the brain. Modern studies have found that aromatic resuscitation herbs can not only restore the permeability of the blood-brain barrier after damage,but also promote drugs to enter the brain through the blood-brain barrier to play a role. The main mechanisms involved are regulating the expression of tight junction proteins and neurotransmitters,acting on transporters,and regulating inflammatory responses. Therefore,this article reviews the mechanism of aromatic resuscitation herbs in regulating the blood-brain barrier after stroke and the development of orifices combined with modern new preparations.