特发性肺纤维化中肺屏障损伤及中药防治研究进展

Research progress on lung barrier injury and traditional Chinese medicine prevention and treatment in idiopathic pulmonary fibrosis

关键词:  肺屏障  肺上皮细胞  肺内皮细胞  特发性肺纤维化  中药

Key words:  lung barrier  pulmonary epithelial cell  pulmonary endothelial cell  idiopathic pulmonary fibrosis  traditional Chinese medicine

摘要:

特发性肺纤维化（IPF）是一种病因不明的进行性肺纤维化疾病，其特征是肺上皮的反复微损伤，肺中上皮-成纤维异常通讯，导致肺中成纤维细胞和细胞外基质的致命积聚，从而损害组织结构和肺功能。由肺上皮、内皮构成的肺屏障损伤被认为是疾病发病的关键事件。然而鲜有文章梳理总结此过程中不同类型细胞被破坏、细胞间的互扰转化、及修复等环节，中药如何发挥针对性的作用也亟需归纳。文章描述了肺屏障在特发性肺纤维化发生过程中的重要性以及通过肺屏障在特发性肺纤维化中的调控机制，包括肺泡上皮屏障的完整性、上皮-间充质转化过程、肺泡上皮细胞的损伤修复和肺泡内皮细胞等，此外，还总结了中药以及天然产物通过调控肺屏障防治特发性肺纤维化的研究进展，为IPF的深入研究和相关药物的开发提供新思路。

Abstract:

Idiopathic pulmonary fibrosis(IPF) is a progressive pulmonary fibrosis disease of unknown etiology,characterized by repeated micro damage to the lung epithelium,abnormal communication between the epithelium and fibroblasts in the lung,leading to fatal accumulation of fibroblasts and extracellular matrix in the lung,thereby damaging tissue structure and lung function. The damage to the lung barrier composed of pulmonary epithelium and endothelium is considered a key event in the onset of diseases. However,there are few articles that summarize the process of different types of cells being destroyed,cell to cell interference transformation,and repair. It is urgent to summarize how traditional Chinese medicine(TCM) can play a targeted role. In this review,we describe the importance of the lung barrier in the development of IPF and its regulatory mechanisms through the lung barrier,including the integrity of the alveolar epithelial barrier,epithelial mesenchymal transition,damage repair of alveolar epithelial cells,and alveolar endothelial cells. In addition,this review summarizes the research progress of TCM and natural products in regulating the lung barrier to prevent and treat IPF,providing new ideas for in-depth research on IPF and the development of related drugs.