从痰饮角度浅析温药改善线粒体功能治疗多囊卵巢综合征思路

A new approach to treating polycystic ovary syndrome by improving mitochondrial function with warm medicine from the perspective of phlegm fluid

关键词:  多囊卵巢综合征  线粒体  中药  痰饮

Key words:  polycystic ovary syndrome  mitochondrion  traditional Chinese medicine  phlegm fluid

摘要:

以肥胖为重要特征的多囊卵巢综合征（PCOS）患者多属脾虚痰湿证，从《金匮要略》提出的“病痰饮者当以温药和之”得出在治疗时可以选用温药，选用温药旨在改善脾主运化及肾阳温煦作用，促进水液代谢，以推动、温化痰饮。线粒体是细胞的能量来源，是氧化磷酸化和形成三磷酸腺苷（ATP）的主要场所，主要功能包括氧化供能、代谢调节、合成蛋白质、维持细胞功能、促进能量代谢等，与中医阳气推动、兴奋、升腾、发散等作用类似，能够促进人体生长发育，增强器官生理功能，推动血液和津液的产生和运行。文章拟从以温药改善线粒体功能，治疗痰湿型PCOS的新角度，为促进中医物质基础的阐释及“温药”在PCOS中的临床应用提供依据和方向。

Abstract:

Polycystic ovary syndrome（PCOS），often characterized by obesity，frequently corresponds to spleen deficiency and phlegm dampness syndrome. According to Jin Gui Yao Lue，patients with phlegm and fluid retention should be treated with warming medicines. The use of these warming medicines aims to enhance the warming effect of kidney yang，thereby improving spleen function，promoting water metabolism，and facilitating the transformation and warming of phlegm and fluids. Mitochondria，the primary site for oxidative phosphorylation and ATP production，serve as the cell’s energy source. Their functions，including oxidative energy supply，metabolic regulation，protein synthesis，maintenance of cellular functions，and facilitation of energy metabolism，are akin to the effects of traditional Chinese medicine（TCM） yang qi in promoting growth，development，organ function，as well as the production and circulation of blood and body fluids. This article presents a novel perspective on treating phlegm-dampness type PCOS by enhancing mitochondrial function with warm medicine，seeking to provide a foundation and direction for interpreting the material basis of TCM and the clinical application of warm medicine in PCOS.