NK细胞在脓毒症中的作用及中药调控其功能防治脓毒症的潜力

The role of NK cells in sepsis and the potential of traditional Chinese medicine to regulate its function in the prevention and treatment of sepsis

关键词:  脓毒症  自然杀伤细胞  免疫治疗  中药  炎症

Key words:  sepsis  natural killer cells  immunotherapy  traditional Chinese medicine  inflammation

摘要:

脓毒症是由细菌等病原微生物侵入机体引起的全身炎症反应综合征，先天免疫反应的失调是导致脓毒症发生和发展的关键影响因素之一。自然杀伤（NK）细胞是先天免疫细胞的重要组成部分，可以通过多种方式识别和攻击异常细胞，在抗感染和维持免疫平衡中发挥作用。多项研究表明，NK细胞的数目以及杀伤活性与脓毒症进程息息相关，许多能有效改善脓毒症的中药也对NK细胞有调控作用。因此文章主要围绕NK细胞在脓毒症中的作用展开，并讨论靶向NK细胞的脓毒症免疫治疗策略以及中药调控NK细胞相关功能防治脓毒症的前景。

Abstract:

Sepsis is a systemic inflammatory response syndrome caused by the invasion of pathogenic microorganisms such as bacteria,and the dysregulation of innate immune response is one of the significant factors leading to the occurrence and development of sepsis. Natural killer cells(NK) are an important part of innate immune cells that can recognize and attack abnormal cells in a variety of ways,playing a role in fighting infection and maintaining immune balance. A number of studies have shown that the quantity and cytotoxic activity of NK cells are closely related to the process of sepsis,and many traditional Chinese medicines(TCM) that can effectively improve sepsis also have a regulatory effect on NK cells. Therefore,this review mainly focused on the role of NK cells in sepsis,and discussed the strategy of sepsis immunotherapy targeting NK cells and the prospect of TCM regulating NK cell-related functions in the prevention and treatment of sepsis.